Effect of Omega-3 Fatty Acid on Cortical Function in ADHD
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 5 - 15 |
| Updated: | 10/12/2018 |
| Start Date: | September 2013 |
| End Date: | March 3, 2017 |
Docosahexaenoic Acid Augmentation of Cortical Attention Networks in ADHD
The study hypothesis is that DHA is more effective than placebo in increasing brain
activation and reducing symptoms in psychostimulant-free children with ADHD.
activation and reducing symptoms in psychostimulant-free children with ADHD.
This study aims to determine the effects of 10-week dietary supplementation with the
long-chain omega-3 fatty acid docosahexaenoic acid (DHA) or placebo on prefrontal cortical
structural and functional connectivity using several neuroimaging techniques: DTI (Diffusion
Tensor Imaging), 1H MRS(Proton Magnetic Resonance Spectroscopy), and fMRI (Functional
Magnetic Resonance Imaging) in psychostimulant-free children with attention deficit
hyperactivity disorder (ADHD). It is postulated that DHA supplements will increase brain
activation and reduce ADHD symptomatology.
long-chain omega-3 fatty acid docosahexaenoic acid (DHA) or placebo on prefrontal cortical
structural and functional connectivity using several neuroimaging techniques: DTI (Diffusion
Tensor Imaging), 1H MRS(Proton Magnetic Resonance Spectroscopy), and fMRI (Functional
Magnetic Resonance Imaging) in psychostimulant-free children with attention deficit
hyperactivity disorder (ADHD). It is postulated that DHA supplements will increase brain
activation and reduce ADHD symptomatology.
Inclusion Criteria:
- Provision of written informed consent/assent
- Ages 5-15 years old
- Meets DSM-IV-TR criteria for ADHD as determined by the KSADS
Exclusion Criteria:
- Contraindication to an MRI scan (i.e., braces, claustrophobia)
- A history of a major medical (e.g., diabetes) or neurological illness (e.g., epilepsy)
- Greater than 1 year outside appropriate age/grade level
- A history of intolerance or hypersensitivity to omega-3 fatty acids
- Currently taking omega-3 supplements
- Not proficient in English language
- Any history of a hematological disorder or concomitant use of anticoagulant
medications
- Personal history of an Axis I psychiatric disorder other than ADHD
- Inability to swallow capsules
We found this trial at
1
site
Cincinnati, Ohio 45219
Principal Investigator: Robert K McNamara, PhD
Phone: 513-558-5601
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