Sequential vs. Monophasic Media Impact Trial (SuMMIT)



Status:Completed
Conditions:Women's Studies, Infertility
Therapuetic Areas:Reproductive
Healthy:No
Age Range:18 - 42
Updated:6/23/2016
Start Date:July 2013
End Date:May 2016

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Trial Summary
Trial Overview
Inclusion Criteria

Evaluation of the Impact of Monophasic vs. Sequential Media on the Reproductive Potential of Embryos Undergoing in Vitro Fertilization (IVF)

To evaluate the impact of two FDA approved culture media on potential of human embryos
resulting from IVF (sequential & monophasic media). Half of each patient's embryos will be
randomly assigned to grow in monophasic media & the other half in sequential media. All
embryos will undergo Comprehensive Chromosome Screening (CCS) & the best euploid embryo from
each group will be transferred resulting in a double embryo transfer (DET). If there are
only euploid embryos from one group, patient will have single embryo transfer (SET)(fresh or
frozen).


Inclusion Criteria:

- Patient undergoing IVF/CCS (no PGD banking)

- Patient meets ASRM guidelines for Double Embryo Transfer (DET)

- Donor Sperm OK

- AMH ≥ 1.2

- FSH ≤ 12

- BAFC ≥12

- Max 1 prior failed IVF cycle for patients 35-45 years old

- Patient <35 years old MUST have 1 prior failed IVF cycle

Exclusion Criteria:

- Chronic endometrial insufficiency

- Use of oocyte donor or gestational carriers

- Medical contraindications to Double Embryo Transfer (DET)

- Male Factor (<100,000 sperm or surgical sperm)

- Communicating hydrosalpinx (on HSG)

- Single gene disorders or sex selection
We found this trial at
1
site
Reproductive Medicine Associates of New Jersey
Basking Ridge, New Jersey 07960
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mi
from
Basking Ridge, NJ
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