A Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy

Inclusion Criteria:

1. Be male or female at least 18 years of age.

2. Have radiating pain toward the buttock down to the leg and/or feet, unilateral.

3. Have radiologic pathology change from L1 - S1 consistent with a disc protrusion,
non-sequestered extrusion, or sequestered fragment, as evidenced by magnetic
resonance imaging (MRI), that is consistent with the clinical signs and symptoms of
lumbar radiculopathy. The MRI must have been performed within 2 months prior to
screening or it will need to be repeated.

4. Have primary leg pain with an average NRS score equal to or greater than 5 as
measured twice a day for five days in each of two weeks during screening.

5. Have failed conservative care for at least 6 weeks. The subject must have been
treated non-operatively (e.g., bed rest, physical therapy, medications, TENS, and/or
manipulation) for a period of at least 6 weeks.

6. Be willing to stop current anti-inflammatory therapy taken for treatment of radicular
pain.

7. Be willing and able to keep a diary that will record study-related information.

8. If sexually active female of childbearing potential, be willing to use an acceptable
method of birth control during the study. Acceptable methods include oral
contraceptives (the pill), IUDs, contraceptive implants under the skin, contraceptive
rings or patches or injections, diaphragms with spermicide, and condoms with
spermicide. Surgical sterilization by tubal ligation or hysterectomy is acceptable.
Women of child bearing potential are defined as women who are <12 months since their
last menstrual cycle prior to screening and have not experienced surgical menopause.

9. Be able to understand the study and provide written informed consent.

Exclusion Criteria:

1. Have a history of lumbar surgery, including vertebroplasty and kyphoplasty.

2. Be ≤ 6 weeks after lumbar ESI or nerve block at start of screening.

3. Have current radicular pain for more than 6 months.

4. Have more than one epidural steroid injection at the affected level to be treated
within the last 6 months.

5. Have demonstrated radiographic changes consistent with subject's symptoms at more
than one level on the baseline MRI.

6. Have symptomatic spinal stenosis of central origin at any level based on CT myelogram
or MRI.

7. Have pain that is localized in the lower back or other sites and is a greater
component of the subject's total pain than the pain in the lower leg and/or foot.

8. Have physical problems that may interfere with any study assessments.

9. Have known infection with human immunodeficiency virus, hepatitis B virus, or
hepatitis C virus.

10. Have presence of local or systemic malignant disease or history of local or systemic
malignant disease in the past 5 years (history of basal cell carcinoma will be
allowed).

11. Have impaired renal function (creatinine >1.5 times upper limit of normal).

12. Have chronic impairment liver function (aspartate aminotransferase [AST] or alanine
aminotransferase [ALT] >3 times upper limit of normal).

13. Have insulin-dependent diabetes or uncontrolled diabetes mellitus (glycosylated
hemoglobin [HbA1c] >7%).

14. Have leukopenia (<3,500 leukocytes/uL).

15. Have current orthostatic hypotension (defined as systolic blood pressure decrease of
at least 20 mmHg or a diastolic blood pressure decrease of at least 10 mmHg or an
increase in heart rate by 20 beats per minute within 3 minutes of standing).

16. Have clinically significant risk for hypotension (e.g., hypotension defined as
systolic reading <90 mmHg and/or diastolic <60 mmHg, hypovolemia, autonomic
neuropathy, or other medical conditions affected by changes in blood pressure).

17. Any clinically significant cardiovascular condition as evidenced by physical exam,
medical history and/or baseline electrocardiogram (ECG).

18. Have evidence of bradycardia as shown by heart rate of <60 beats per minute via
screening ECG.

19. Have any poorly-controlled or serious medical condition, psychiatric illness, or
clinically significant laboratory value that, in the opinion of the investigator,
could compromise the safety of the subject or the scientific integrity of the study
(e.g., uncontrolled hypertension, autoimmune disease, or clinically relevant symptoms
of thyroid dysfunction).

20. Have cauda equina syndrome.

21. Have neurological deficits, as determined by the investigator, which would interfere
with the assessments required by the protocol.

22. Have been previously diagnosed with peripheral neuropathy.

23. Have vascular claudication, as determined by the investigator, which would interfere
with the assessments required by the protocol.

24. Have a history or evidence of bleeding disorder (e.g., hemophilia, disseminated
intravascular coagulation disorder [DIC], or thrombocytopenia [TCP])

25. Have greater than 3 mm spondylolisthesis at the affected level.

26. Have BMI greater than or equal to 40, or with any anatomic issues that may interfere
with placement of the MDT-15 pellets as noted by the Investigator.

27. Have a diagnosis of major depression.

28. Have sustained a vertebral or hip fracture within the last year.

29. Have known or suspected allergy or hypersensitivity to clonidine, lidocaine, contrast
media, opioids, any medication that may be given as part of the site's standard of
care related to the study drug implantation procedure, or any other medication that
may be given as treatment during the study.

30. Have a known or suspected allergy to polylactic acid (found in products such as
Lupron Depot®, Atridox®, some types of dermal fillers, and some types of sutures).

31. If female, be pregnant or breastfeeding, or desiring to become pregnant during the
trial.

32. Have taken an investigational drug or used an investigational device within the past
30 days or intending to use an investigational drug or device during the trial.

33. Have active alcoholism or drug dependency, as determined by the investigator

34. Be currently on worker's compensation or in litigation related to injury or medical
condition.

35. Be in circumstances which make it difficult to maintain a usual nighttime sleep
schedule (e.g., the subject works on an evening/night shift or otherwise has a work
or activity schedule which could confound or interfere with study assessments).

36. Have current treatment with any of the following medications:

1. Systemic corticosteroids (intranasal/inhaled steroids are acceptable).

2. Immunosuppressant therapy to treat autoimmune diseases (e.g., rheumatoid
arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus,
sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's
Disease, pemphigus, and ulcerative colitis).

3. Oral or topical products that contain clonidine (e.g., Catapres).

4. Herbal supplements that contain yohimbine.

5. Anti-coagulant therapy (prophylactic aspirin at 81mg/day is acceptable). If
applicable, aspirin therapy should be held before and after the study procedure
based on the investigator's discretion.

6. Calcium channel blocker, digoxin, or beta-adrenergic blockers.

37. Have chronic use of opioids (including tramadol), defined as use 20 out of the last
30 days prior to study screening.

38. Have emotional or health concerns (in the judgment of the investigator) that may
compromise the safety of the subject, may make compliance difficult, or may confound
the reliability of information acquired in this study.