Loaded and Unloaded Magnetic Resonance (MR) Imaging of Meniscus-Cartilage-Trabecular Bone in Osteoarthritis

Variables of gait mechanics during walking have been linked to the onset and progression of
knee osteoarthritis (OA). The knee adduction moment is one key variable that has been
identified as an important indicator of medial compartment loads across the knee joint. Use
of gait-retraining strategies to alter gait movement patterns and lower the knee adduction
movement in persons with knee OA is a new and promising direction for the potential
intervention in a population in which few strategies have worked successfully.

Factors that affect cartilage composition are crucial to understanding the disease
mechanisms in knee OA. A multi-scale approach towards understanding the knee OA disease
process by evaluating tissue compositional changes, joint contact mechanics, whole-body
neuromuscular dynamics, and functional performance. The results will be the first to show
the association between cartilage composition and daily function (performance and patterns)
which are implicated in OA development and progression. With the addition of comprehensive
muscle testing (cross sectional area/volume assessment using MR, strength testing, muscle
activation and co-contraction patterns during daily activities), it will be possible to
study the interaction between all major tissues around the knee.

Inclusion Criteria:

- Men and women

- At least 35 years of age

- Mild OA patients with arthritic knee symptoms and KL score of 1-2

- Severe OA patients with arthritic knee symptoms and KL score of 3-4

- Knee symptoms in OA patients is defined as pain, aching, or stiffness on most days of
a month during the past year or use of medication for treatment of knee pain on most
days of a month during the past year

- self reported knee pain (defined as medial compartment knee pain at least 1 day per
week during each of the 6 weeks prior to participation) and at least 3 of the
following 6 clinical indicators: Age>50 years; morning stiffness<30 minutes duration;
crepitus on active motion; tenderness of the bony margins of the knee joint; bony
enlargement at the knee; and lack of palpable warmth of the synovium

Exclusion Criteria:

- current use of investigational drug

- conditions other than OA which limit lower extremity function and mobility and/or
would confound the evaluation of function (e.g., clinically significant spinal disc
degeneration, painful or dysfunctional feet, peripheral vascular disease, lumbar
radiculopathy, trochanteric bursitis, hip pain, lumbar pain)

- Patients with metallic fragments in the eyes, vascular clips, pacemakers, and other
contraindications to MRI

- History of joint replacement, intra-articular fracture, osteotomy, arthroplasty or
meniscectomy of the signal knee

- History of other disease that may involve the study joint including systemic
inflammatory disease, crystalline disease, knee infection of the signal knee,
avascular necrosis, Paget's disease or tumors

- Self reported heart condition that limits any daily physical activity

- Patients who are pregnant