Bicuspid Valve Aortopathy Feasibility Study

The study will consider all patients with a bicuspid aortic valve and 1) determine the number
of patients needed to be screened for a clinical trial, based on patient eligibility
percentages applying specific inclusion and exclusion criteria, 2) for those meeting these
criteria, follow changes in and compliance with medical therapy over two years, and 3) in a
limited subset of eligible patients, perform MRI at baseline and after 2 years to measure the
change in aortic area over time.

Inclusion Criteria:

- Bicuspid aortic valve

- Aortic measurement of 35 - 49 mm on prior imaging study

Exclusion Criteria:

- Prior aortic valve or thoracic aortic surgery

- Prior aortic dissection

- Other condition associated with enlarged aorta including Coarctation, Marfans, Turner
syndrome, Loeys-Dietz, etc.

- Severe aortic stenosis or regurgitation

- Contraindication to MRI such as claustrophobia or implanted pacer/defibrillator

- Anticipated pregnancy, surgery, or move outside the area within 2 years