Mechanisms of Diabetes Control After Weight Loss Surgery, Sub-study #1
| Status: | Withdrawn |
|---|---|
| Conditions: | Diabetes, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 20 - 60 |
| Updated: | 4/21/2016 |
| Start Date: | September 2008 |
| End Date: | September 2014 |
Gastric bypass (GBP) and laparoscopic adjustable banding (AGB) are common procedures that
can result in significant weight loss and significantly improve type 2 diabetes in 40-80% of
cases. The mechanism and time course of these changes have not been well studied and are
poorly understood. The primary aim of this study is to investigate the potential
weight-independent mechanisms of diabetes remission after GBP, by comparing GBP and AGB
subjects after similar weight loss.
can result in significant weight loss and significantly improve type 2 diabetes in 40-80% of
cases. The mechanism and time course of these changes have not been well studied and are
poorly understood. The primary aim of this study is to investigate the potential
weight-independent mechanisms of diabetes remission after GBP, by comparing GBP and AGB
subjects after similar weight loss.
All participants will be tested before and then after 10 and 20-30% weight loss after either
GBP or AGB surgery. Subjects will undergo an oral glucose tolerance test (OGTT) an
isoglycemic intravenous glucose test (IVGT) to assess the incretin effect, a measure of
insulin sensitivity by an intravenous insulin sensitivity test (IVGTT) and body composition
measurements.
GBP or AGB surgery. Subjects will undergo an oral glucose tolerance test (OGTT) an
isoglycemic intravenous glucose test (IVGT) to assess the incretin effect, a measure of
insulin sensitivity by an intravenous insulin sensitivity test (IVGTT) and body composition
measurements.
Inclusion Criteria:
- obese type 2 diabetes individuals scheduled to undergo bariatric surgery by either
gastric banding or gastric bypass surgery
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