Oxytocin Infusions and Blood Loss in Patients Undergoing Elective Cesarean Delivery.
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 4/2/2016 |
| Start Date: | August 2013 |
| End Date: | September 2014 |
| Contact: | Alexander J Butwick, F.R.C.A. |
| Email: | ajbut@stanford.edu |
| Phone: | (650) 736-8513 |
Effects of Different Oxytocin Infusions on Blood Loss and Postpartum Hemoglobin Values in Patients Undergoing Elective Cesarean Delivery
Although prior dose-finding studies have investigated the optimal bolus dose of oxytocin to
initiate adequate uterine tone, it is unclear what oxytocin infusion regimen is required to
maintain adequate uterine tone after delivery. The study investigators aim to compare two
different infusion rates of oxytocin to assess the optimal infusion regimen for reducing
blood loss in women undergoing elective Cesarean delivery.
initiate adequate uterine tone, it is unclear what oxytocin infusion regimen is required to
maintain adequate uterine tone after delivery. The study investigators aim to compare two
different infusion rates of oxytocin to assess the optimal infusion regimen for reducing
blood loss in women undergoing elective Cesarean delivery.
Oxytocin (pitocin) is a drug commonly used in obstetric practice, and the drug effect is to
increase the muscular tone of the uterus to reduce uterine bleeding after neonatal delivery.
Pregnant patients undergoing elective (scheduled)Cesarean delivery routinely receive
oxytocin after delivery of the baby. Post-delivery, oxytocin is commonly administered as an
IV bolus and/or infusion. No previous studies have accurately assessed differences in
oxytocin infusions after delivery in patients undergoing elective cesarean delivery. Thus
the study aim is to investigate which infusion rate can optimally provide adequate
maintenance of uterine tone during Cesarean delivery while being associated with minimal or
no maternal side-effects.
increase the muscular tone of the uterus to reduce uterine bleeding after neonatal delivery.
Pregnant patients undergoing elective (scheduled)Cesarean delivery routinely receive
oxytocin after delivery of the baby. Post-delivery, oxytocin is commonly administered as an
IV bolus and/or infusion. No previous studies have accurately assessed differences in
oxytocin infusions after delivery in patients undergoing elective cesarean delivery. Thus
the study aim is to investigate which infusion rate can optimally provide adequate
maintenance of uterine tone during Cesarean delivery while being associated with minimal or
no maternal side-effects.
Inclusion Criteria:
- Healthy pregnant patients with uncomplicated pregnancies:
- ASA (American Association of Anesthesiologists) class 1 or 2 patients.
- Singleton pregnancies.
Exclusion Criteria:
- ASA class 3 or 4 patients.
- Known drug allergy to intravenous oxytocin.
- Significant medical or obstetric disease.
- Known uterine abnormality.
- Known placental abnormality.
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