Alpha-1 Anti-Trypsin (AAT) Treatment in Acute Myocardial Infarction

Inclusion Criteria:

- Acute STEMI defined as chest pain (or equivalent) with an onset within 12 hours and
ECG evidence of ST segment elevation (>1 mm) in 2 or more anatomically contiguous
leads that is new or presumably new

- Planned or completed coronary angiogram for potential intervention

- Age>21

Exclusion Criteria:

- Inability to give informed consent

- Hemodynamic instability as defined as need for inotropic or vasoactive agents, or
need for mechanical support devices (including intra-aortic balloon pump)

- Pregnancy

- Preexisting congestive heart failure (American Heart Association/American College of
Cardiology class C-D, New York Heart Association III-IV)

- Preexisting severe left ventricular dysfunction (EF<20%)

- Preexisting severe valvular heart disease

- Known active infections (acute or chronic)

- Recent (<14 days) or active use of anti-inflammatory drugs (not including NSAIDs or
corticosteroids used for IV dye allergy only)

- Known chronic inflammatory disease (including but not limited to rheumatoid
arthritis, systemic lupus erythematosus)

- Known active malignancy of any type, or prior diagnosis in the past 10 years

- Anticipated need for cardiac or major surgery

- Known active cancer (or prior diagnosis of cancer within the past 10 years)

- Known Immunoglobulin A (IgA) deficiency