Supplemental Parenteral Nutrition in Pediatric Respiratory Failure
| Status: | Recruiting |
|---|---|
| Conditions: | Food Studies, Hospital, Pulmonary |
| Therapuetic Areas: | Pharmacology / Toxicology, Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | Any - 16 |
| Updated: | 4/17/2018 |
| Start Date: | August 2013 |
| End Date: | August 2018 |
| Contact: | Katri V. Typpo, MD, MPH |
| Email: | ktyppo@peds.arizona.edu |
| Phone: | 5206265485 |
Optimal delivery of nutritional support during critical illness is central to appropriate
intensive care unit management, and yet fundamental gaps in knowledge exist regarding timing,
route, dose, and type of nutritional support for critically ill infants and children.
Understanding how to optimize nutritional support during pediatric critical illness is
important because even brief periods of malnutrition in infancy result in permanent negative
effects on long-term neurocognitive development. Optimized nutrition support is a way to
improve morbidity for survivors of pediatric critical illness. Parenteral nutrition (PN)
supplementation could improve long-term neurocognitive outcome for pediatric critical illness
by preventing acute malnutrition, but has unknown effects on intestinal barrier function; a
proposed mechanism for late sepsis and infectious complications during critical illness.
While randomized controlled trials (RCT) support early PN in premature infants and late PN in
critically ill adults, the optimal time to begin PN is unknown for critically ill infants and
children. Acute malnutrition may develop within 48 hours of admission in critically ill
infants and children, and repleted energy stores are predictive of survival. And yet, due to
concerns for PN-associated infectious morbidity, current PICU standard of care is to
supplement with PN only in children who fail to enterally feed, as late as 7 days into their
admission. Delays in nutrition may have long-term effects on cognitive outcome in older
infants and children. In premature infants, PN begun within hours of birth results in
improved 18-month neurocognitive outcome without an increase in infectious complications. An
RCT is needed to determine if early PN in critically ill infants and children prevents acute
malnutrition and improves short and long-term outcomes of PICU hospitalization.
The central hypothesis of this proposal is that optimized early protein and calorie delivery
will improve nutritional outcomes and intestinal barrier function for critically ill infants
and children. The overall purpose of this study is to evaluate the efficacy and safety of
early PN as a supplement to enteral nutrition to improve nutritional delivery, nutritional
outcomes, and intestinal barrier function for infants and children with acute respiratory
failure who are mechanically ventilated in the pediatric intensive care unit.
intensive care unit management, and yet fundamental gaps in knowledge exist regarding timing,
route, dose, and type of nutritional support for critically ill infants and children.
Understanding how to optimize nutritional support during pediatric critical illness is
important because even brief periods of malnutrition in infancy result in permanent negative
effects on long-term neurocognitive development. Optimized nutrition support is a way to
improve morbidity for survivors of pediatric critical illness. Parenteral nutrition (PN)
supplementation could improve long-term neurocognitive outcome for pediatric critical illness
by preventing acute malnutrition, but has unknown effects on intestinal barrier function; a
proposed mechanism for late sepsis and infectious complications during critical illness.
While randomized controlled trials (RCT) support early PN in premature infants and late PN in
critically ill adults, the optimal time to begin PN is unknown for critically ill infants and
children. Acute malnutrition may develop within 48 hours of admission in critically ill
infants and children, and repleted energy stores are predictive of survival. And yet, due to
concerns for PN-associated infectious morbidity, current PICU standard of care is to
supplement with PN only in children who fail to enterally feed, as late as 7 days into their
admission. Delays in nutrition may have long-term effects on cognitive outcome in older
infants and children. In premature infants, PN begun within hours of birth results in
improved 18-month neurocognitive outcome without an increase in infectious complications. An
RCT is needed to determine if early PN in critically ill infants and children prevents acute
malnutrition and improves short and long-term outcomes of PICU hospitalization.
The central hypothesis of this proposal is that optimized early protein and calorie delivery
will improve nutritional outcomes and intestinal barrier function for critically ill infants
and children. The overall purpose of this study is to evaluate the efficacy and safety of
early PN as a supplement to enteral nutrition to improve nutritional delivery, nutritional
outcomes, and intestinal barrier function for infants and children with acute respiratory
failure who are mechanically ventilated in the pediatric intensive care unit.
Inclusion Criteria:
1. Admitted to study hospital pediatric intensive care unit (PICU),
2. One month to 16 years of age,
3. Exhibits Acute Hypoxemic Respiratory Failure as defined as: PaO2/FiO2 ≤ 300 or
SpO2/FiO2 ≤ 260, No evidence of cardiac dysfunction, Mechanically ventilated,
4. Require artificial nutrition,
5. Anticipate placement of central venous line within 24 hours of admission
Exclusion Criteria:
1. Premature infants and neonates < 37 weeks corrected gestational age,
2. Transfer patient on an established enteral or parenteral nutritional regimen,
3. Known allergy to lactulose or mannitol,
4. Pregnant,
5. Admit BMI >30,
6. Thoracic trauma, abdominal trauma, and/or active intracranial bleeding,
7. Anuric renal failure, previous bowel surgery and/or short gut syndrome,
8. Cannot be enterally fed within 24 hours of admission according to the admitting
physician,
9. On extracorporeal membrane oxygenation (ECMO),
10. Expected survival <24 hours or limitations to aggressive ICU care (DNR),
11. Receiving active CPR when admitted to the PICU,
12. A pre-existing bronchopleural fistula,
13. Previously enrolled and randomized into this protocol,
14. Actively enrolled in another clinical trial which at the discretion of the PI would
conflict with this study.
We found this trial at
1
site
Tucson, Arizona 85724
Principal Investigator: Katri V. Typpo, MD, MPH
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