Resistance and Cardiorespiratory Time-matched Exercise in Youth: A Randomized Clinical Trial (RCT:RCT)
| Status: | Terminated |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 12 - 17 |
| Updated: | 6/29/2017 |
| Start Date: | October 2013 |
| End Date: | June 21, 2017 |
The current epidemic rate of childhood obesity is a leading health concern as
overweight/obese youth may suffer from comorbid conditions, once considered exclusive to
adults. It has been suggested that physical inactivity is a major determinant of obesity and
obesity-related health risk in children and adolescents. Recent studies in adults report
that the combination of aerobic and resistance exercise is a better strategy than aerobic or
resistance exercise alone for reducing risk factors for type 2 diabetes. Currently, the most
effective exercise modality for concurrent reductions of adiposity, in particular abdominal
fat, and risk factors for type 2 diabetes and cardiovascular disease (CVD) is unknown in
adolescents. Therefore, we will employ a randomized trial to examine the effects of a
long-term aerobic exercise, resistance exercise, and a combination of both exercise regimens
on: 1) in vivo insulin sensitivity, glucose tolerance and risk for type 2 diabetes, 2) total
adiposity, skeletal muscle mass, visceral adiposity and ectopic fat in the liver and
skeletal muscle, and 3) traditional and non-traditional risk factors/markers for CVD in
overweight boys and girls. We will recruit 168 sedentary overweight (BMI >85th percentile)
adolescent boys and girls aged 12-17 years old and randomly assign them to one of three
6-month intervention groups (n = 56 each group): 1) aerobic exercise (180 min/week), 2)
resistance exercise (180 min/week), or 3) aerobic and resistance exercise (180 min/week)
group. A weight maintenance diet (55-60% carbohydrate, 15-20% protein, and 25-30% fat) will
be prescribed and monitored for all groups, so that any changes in energy balance will be
induced by exercise intervention alone (e.g., no calorie restriction). We believe that this
proposed application will have a significant implication that is directly relevant for one
in three American adolescents who are at increased risk of developing obesity-related
co-morbidities.
overweight/obese youth may suffer from comorbid conditions, once considered exclusive to
adults. It has been suggested that physical inactivity is a major determinant of obesity and
obesity-related health risk in children and adolescents. Recent studies in adults report
that the combination of aerobic and resistance exercise is a better strategy than aerobic or
resistance exercise alone for reducing risk factors for type 2 diabetes. Currently, the most
effective exercise modality for concurrent reductions of adiposity, in particular abdominal
fat, and risk factors for type 2 diabetes and cardiovascular disease (CVD) is unknown in
adolescents. Therefore, we will employ a randomized trial to examine the effects of a
long-term aerobic exercise, resistance exercise, and a combination of both exercise regimens
on: 1) in vivo insulin sensitivity, glucose tolerance and risk for type 2 diabetes, 2) total
adiposity, skeletal muscle mass, visceral adiposity and ectopic fat in the liver and
skeletal muscle, and 3) traditional and non-traditional risk factors/markers for CVD in
overweight boys and girls. We will recruit 168 sedentary overweight (BMI >85th percentile)
adolescent boys and girls aged 12-17 years old and randomly assign them to one of three
6-month intervention groups (n = 56 each group): 1) aerobic exercise (180 min/week), 2)
resistance exercise (180 min/week), or 3) aerobic and resistance exercise (180 min/week)
group. A weight maintenance diet (55-60% carbohydrate, 15-20% protein, and 25-30% fat) will
be prescribed and monitored for all groups, so that any changes in energy balance will be
induced by exercise intervention alone (e.g., no calorie restriction). We believe that this
proposed application will have a significant implication that is directly relevant for one
in three American adolescents who are at increased risk of developing obesity-related
co-morbidities.
Inclusion Criteria:
Age 12-17 years
- BMI percentile for age and sex >-85% percentile and BMI <40 kg/m2
- No structured physical activity in the past 3 months prior to the study (not
including school physical education classes)
- No significant weight changes (>2-3 kg/m2) in the past 3 months prior to the study
Exclusion Criteria:
- Endocrine disorders (e.g., polycystic ovary syndrome, diabetes)
- Syndromic obesity
- Positive pregnancy test
- Use of chronic medications which influence glucose metabolism and body composition
- Chronic medical/psychiatric conditions preventing the ability to participate in the
study.
- Anemia
We found this trial at
1
site
4401 Penn Avenue
Pittsburgh, Pennsylvania 15224
Pittsburgh, Pennsylvania 15224
412-692-5325
Principal Investigator: SoJung Lee, PhD
Phone: 412-692-5147
Children's Hospital of Pittsburgh of UPMC UPMC is one of the leading nonprofit health systems...
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