Effects of Exercise on Memory in Healthy and Brain-Injured Individuals
| Status: | Terminated |
|---|---|
| Conditions: | Hospital, Neurology |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 8/31/2017 |
| Start Date: | August 31, 2013 |
| End Date: | August 28, 2017 |
Acute Effects of Exercise on Memory in Healthy and Brain-Injured Individuals
Background:
- Research has shown that one exercise session may improve a person s ability to recall
information they learned before the exercise. Knowing how exercise changes brain activity to
improve memory can help researchers understand how memory works and how to improve it in
people with memory problems. This study compares two kinds of exercise on a stationary bike
for their ability to temporarily improve memory on certain tests. Researchers will look at
the effect of exercise on body chemistry by drawing blood and collecting saliva.
Objectives:
- To understand how a single session of exercise affects memory testing in healthy people and
people who have had traumatic brain injury (TBI).
Eligibility:
- Adults ages 18 through 45 with TBI.
- Healthy adult volunteers, ages 18 through 45.
Design:
- Participants will be screened with medical history and physical exam. This will take
about 1 hour.
- Participants with TBI will also be screened with a test of their memory. This will take
another hour.
- Visit 1 will take about 3 hours. Participants will:
- Have a tube inserted in their arm for drawing blood during the tests.
- Take memory tests. They will look at pictures, symbols, and words, then answer
questions.
- Give a saliva sample by chewing on a small sponge for 2 minutes.
- Exercise on a stationary bike.
- Take the memory tests again.
- Visit 2 will take place 1 week later. Participants will take the memory tests only.
- Research has shown that one exercise session may improve a person s ability to recall
information they learned before the exercise. Knowing how exercise changes brain activity to
improve memory can help researchers understand how memory works and how to improve it in
people with memory problems. This study compares two kinds of exercise on a stationary bike
for their ability to temporarily improve memory on certain tests. Researchers will look at
the effect of exercise on body chemistry by drawing blood and collecting saliva.
Objectives:
- To understand how a single session of exercise affects memory testing in healthy people and
people who have had traumatic brain injury (TBI).
Eligibility:
- Adults ages 18 through 45 with TBI.
- Healthy adult volunteers, ages 18 through 45.
Design:
- Participants will be screened with medical history and physical exam. This will take
about 1 hour.
- Participants with TBI will also be screened with a test of their memory. This will take
another hour.
- Visit 1 will take about 3 hours. Participants will:
questions.
- Visit 2 will take place 1 week later. Participants will take the memory tests only.
Objective: The goals of this study are to 1. replicate the finding that exercise after
exposure to images enhances their subsequent recall, 2. extend the question to words and
logical rules, 3. examine the mechanism of the effect using exercise biomarkers and fMRI and
4. explore its usefulness as an aid to memory in individuals with traumatic brain injury
(TBI).
Study population: Healthy adult volunteers and individuals with TBI.
Design: The main, clinical, experiment has a parallel, repeated-measures design, where four
groups (two each of healthy subjects and participants with TBI) will encode pictures, words
and rules and then exercise at either a high or very low (placebo) intensity. Recall will be
tested one hour and again at seven days after exercise. Blood and saliva will be collected
before and immediately after exercise and assayed for biomarkers of exercise, thought to be
possible mediators of the memory effect. In a parallel-design fMRI experiment, intended to
explore the brain basis of the effect of exercise on memory, healthy volunteers will view
pictures, exercise at a high or low intensity, and then perform a recall task in the scanner.
The analysis will look for differences in location and extent of evoked brain activations
evoked by picture recall after low and high intensity exercise.
Outcome measures: The primary outcome measure is recall of visual material one hour after
exercise. Secondary measures will be the recall of word lists and letter/digit symbol
matching (logical memory) and activations on fMRI. The blood and saliva biomarkers will are
included as exploratory outcomes.
exposure to images enhances their subsequent recall, 2. extend the question to words and
logical rules, 3. examine the mechanism of the effect using exercise biomarkers and fMRI and
4. explore its usefulness as an aid to memory in individuals with traumatic brain injury
(TBI).
Study population: Healthy adult volunteers and individuals with TBI.
Design: The main, clinical, experiment has a parallel, repeated-measures design, where four
groups (two each of healthy subjects and participants with TBI) will encode pictures, words
and rules and then exercise at either a high or very low (placebo) intensity. Recall will be
tested one hour and again at seven days after exercise. Blood and saliva will be collected
before and immediately after exercise and assayed for biomarkers of exercise, thought to be
possible mediators of the memory effect. In a parallel-design fMRI experiment, intended to
explore the brain basis of the effect of exercise on memory, healthy volunteers will view
pictures, exercise at a high or low intensity, and then perform a recall task in the scanner.
The analysis will look for differences in location and extent of evoked brain activations
evoked by picture recall after low and high intensity exercise.
Outcome measures: The primary outcome measure is recall of visual material one hour after
exercise. Secondary measures will be the recall of word lists and letter/digit symbol
matching (logical memory) and activations on fMRI. The blood and saliva biomarkers will are
included as exploratory outcomes.
- INCLUSION CRITERIA:
- Age 18-45 (inclusive)
- English speaking and writing
- For TBI patients:
- History of TBI (defined according to the American Congress of Rehabilitation
Medicine Criteria: History of having sustained a traumatically induced
physiological disruption of brain function at least 2 months before
participation)
- Evidence of at least moderate TBI severity. Evidence for intensity of TBI will be
any one of the following 3 criteria:
1. GCS greater than or equal to 9 (obtained in Emergency Room and noted in
medical record)
2. Post-traumatic amnesia > 24 hours
3. TBI-related abnormality on neuroimaging (either CT or MRI)
- Documented memory deficit, i.e., a score of 1 standard deviation or more below
age-adjusted norm on a recognized clinical test of memory, such as the Wexler
Memory Scale, within the last two years.
- Enrollment in Protocol 11-N-0084
- Right-handedness for fMRI participants
EXCLUSION CRITERIA:
- Inability to give informed consent
- History of major neurological or psychiatric illness, e.g., neurodegenerative
disorder, stroke, congenital or genetic disorder, currently symptomatic major
depressive disorder, schizophrenia
- History of exercise intolerance
- Any finding on examination indicative of cardiac or respiratory compromise
- History of heart disease
- History of pulmonary disease, other than controlled, non-exercise-induced asthma
- History of uncontrolled diabetes
- Resting heart rate > 100 BPM
- Resting systolic blood pressure > 140 mmHg or diastolic blood pressure > 100 mmHg
- Peripheral condition making completion of the exercise protocol impossible, such as
severe osteoarthritis or chronic pain
- Pregnancy
- For healthy subjects undergoing MRI:
- Ferromagnetic metal in the cranial cavity or eye, e.g. aneurysm clip, implanted
neural stimulator, cochlear implant, or ocular foreign body
- Implanted cardiac pacemaker or auto-defibrillator or pump
- Non-removable body piercing
- Claustrophobia
- Inability to lie supine for two hours
- Any structural brain abnormality, such as tumor or stroke
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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