Changes in Oral Contraceptive Hormones After Gastric Bypass Surgery
| Status: | Withdrawn |
|---|---|
| Conditions: | Contraception, Contraception |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 4/17/2018 |
| Start Date: | April 2013 |
| End Date: | December 6, 2017 |
Impact of Gastric Bypass Surgery on the Pharmacokinetics of Oral Contraceptive Hormones
This study will attempt to determine whether having gastric bypass surgery changes the way
that the gut absorbs hormones from birth control pills. It is believed that, because gastric
bypass surgery causes malabsorption of nutrients and some medications, the levels of birth
control hormones after the surgery will be lower than in women before they have the surgery.
The investigators will ask several women to take a pack of birth control pills before having
bypass surgery, and then another pack several months after surgery. The investigators will
measure hormone levels in the blood. The investigators will also measure outcomes that may
tell us how well the birth control pills are working, such as ultrasounds of the uterus and
ovaries, and examination of the cervix.
that the gut absorbs hormones from birth control pills. It is believed that, because gastric
bypass surgery causes malabsorption of nutrients and some medications, the levels of birth
control hormones after the surgery will be lower than in women before they have the surgery.
The investigators will ask several women to take a pack of birth control pills before having
bypass surgery, and then another pack several months after surgery. The investigators will
measure hormone levels in the blood. The investigators will also measure outcomes that may
tell us how well the birth control pills are working, such as ultrasounds of the uterus and
ovaries, and examination of the cervix.
Inclusion Criteria:
- Planning to undergo gastric bypass surgery at our institution
- willing to take 2 monthly cycles of the oral contraceptive: one cycle before and one
after surgery
- use of Depo-provera within 6 months of enrollment
- Use of implantable or intrauterine contraception
- able to attend multiple study visits
Exclusion Criteria:
- Any contraindication to combined hormonal contraceptive use
- Surgical complications precluding further participation
We found this trial at
1
site
4940 Eastern Ave
Baltimore, Maryland 21224
Baltimore, Maryland 21224
(410) 550-0100
Phone: 410-550-0336
Johns Hopkins Bayview Medical Center There is no better story in American medicine in the...
Click here to add this to my saved trials
