The Head Injury-associated Photosensitivity and Pupillary Function (HIPP) Study
| Status: | Completed |
|---|---|
| Conditions: | Hospital, Neurology, Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery, Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/8/2014 |
| Start Date: | August 2013 |
| End Date: | December 2014 |
| Contact: | Andrew Hartwick, OD, PhD |
| Email: | hartwick.4@osu.edu |
| Phone: | 614-688-8308 |
After a head injury, many people find that exposure to light causes them increased
discomfort. By measuring how the pupil in the eye constricts to flashes of red and blue
light, this study will investigate whether this phenomenon is due to a change in the eye's
sensitivity to light.
discomfort. By measuring how the pupil in the eye constricts to flashes of red and blue
light, this study will investigate whether this phenomenon is due to a change in the eye's
sensitivity to light.
The pupils inside the eyes constrict in response to light stimulation. Different classes of
cells within the human retina initiate this response. Recent research suggests that one of
the ganglion cell types involved in this pupil response also plays a role in the photophobia
experienced by migraine sufferers. The main aim of this study is to determine whether this
type of ganglion cell becomes 'hypersensitive' after traumatic brain injury, thereby
contributing to symptoms of increased photosensitivity experienced by many of these
individuals.
In the first session of this study, subjects will be asked questions about their sensitivity
to light and the reaction of their eyes' pupils to flashing red and blue lights will be
measured. The subjects will be given a full eye examination to rule out other causes of
increased photosensitivity.
In some cases, subjects will be asked to attend a second session roughly two weeks later.
They will be asked to wear a watch that measures their daily activity/sleep rhythms and
light exposure during this inter-session period. During the second session, further testing
of the pupil responses to blue and red flickering light will be performed.
cells within the human retina initiate this response. Recent research suggests that one of
the ganglion cell types involved in this pupil response also plays a role in the photophobia
experienced by migraine sufferers. The main aim of this study is to determine whether this
type of ganglion cell becomes 'hypersensitive' after traumatic brain injury, thereby
contributing to symptoms of increased photosensitivity experienced by many of these
individuals.
In the first session of this study, subjects will be asked questions about their sensitivity
to light and the reaction of their eyes' pupils to flashing red and blue lights will be
measured. The subjects will be given a full eye examination to rule out other causes of
increased photosensitivity.
In some cases, subjects will be asked to attend a second session roughly two weeks later.
They will be asked to wear a watch that measures their daily activity/sleep rhythms and
light exposure during this inter-session period. During the second session, further testing
of the pupil responses to blue and red flickering light will be performed.
Inclusion Criteria:
- 18+ years old
- reports a previous head injury that occurred at least 6 months ago
- score of 2 or 3 (mild TBI) on OSU-TBI ID Survey
- best-corrected visual acuity of at least 20/30 in both eyes
- reliable visual field
Exclusion Criteria:
- pregnancy
- significant afferent pupillary defect
- previous history of neurodegenerative disease
- intraocular pressure more than 21 mm Hg
- significant visual field defect
- active corneal pathology
- history of retinal or optic nerve disease
- strabismus (eye turn)
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