Blackberry Flavonoid Absorption and Effects on Intestinal Bacteria
| Status: | Completed |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 25 - 75 |
| Updated: | 1/1/2014 |
| Start Date: | September 2013 |
| End Date: | April 2014 |
| Contact: | Sarah K Gebauer, Ph.D. |
| Email: | sarah.gebauer@ars.usda.gov |
Intestinal bacteria can metabolize unabsorbed polyphenols (plant compounds) to produce
smaller molecules which may impact health. In addition, evidence suggests that this process
may be affected by body fatness. This study aims to investigate absorption of blackberry
polyphenols, their impact on intestinal bacteria, polyphenol metabolites formed by
intestinal bacteria, and how these processes differ for obese and lean individuals. It is
hypothesized that polyphenol absorption and metabolism will differ between obese and lean
individuals and that differences in intestinal microbiota may play a role.
smaller molecules which may impact health. In addition, evidence suggests that this process
may be affected by body fatness. This study aims to investigate absorption of blackberry
polyphenols, their impact on intestinal bacteria, polyphenol metabolites formed by
intestinal bacteria, and how these processes differ for obese and lean individuals. It is
hypothesized that polyphenol absorption and metabolism will differ between obese and lean
individuals and that differences in intestinal microbiota may play a role.
Inclusion Criteria:
- 25-75 years old
Exclusion Criteria:
- Use of blood-thinning medications such as Coumadin (warfarin), Dicumarol (dicumarol),
or Miradon (anisindione)
- Presence of any gastrointestinal disease, metabolic disease, or malabsorption
syndromes that may interfere with the study goals
- Have been pregnant during the previous 12 months, are currently pregnant or
lactating, or plan to become pregnant during the study
- Type 2 diabetes requiring the use of oral antidiabetic agents or insulin
- Fasting triglycerides greater than 300 mg/dL
- Fasting glucose greater than 126 mg/dL
- History of eating disorders or other dietary patterns which are not consistent with
the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets)
- Use of prescription or over-the-counter antiobesity medications or supplements (e.g.,
phenylpropanolamine, ephedrine, caffeine) during and for at least 6 months prior to
the start of the study or a history of a surgical intervention for obesity
- Active cardiovascular disease (such as a heart attack or procedure within the past
three months or participation in a cardiac rehabilitation program within the last
three months, stroke, or history/treatment for transient ischemic attacks in the past
three months, or documented history of pulmonary embolus in the past six months).
- Use of any tobacco products in past 3 months
- Unwillingness to abstain from herbal supplements for two weeks prior to the study and
during the study
- Known (self-reported) allergy or adverse reaction to blackberries or other study
foods
- Unable or unwilling to give informed consent or communicate with study staff
- Self-report of alcohol or substance abuse within the past twelve months and/or
current acute treatment or rehabilitation program for these problems (Long-term
participation in Alcoholics Anonymous is not an exclusion)
- Other medical, psychiatric, or behavioral factors that in the judgment of the
Principal Investigator may interfere with study participation or the ability to
follow the intervention protocol
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