Magnetic Resonance Imaging (MRI) in Amyotrophic Lateral Sclerosis (ALS)
| Status: | Withdrawn |
|---|---|
| Conditions: | Neurology, Neurology, Neurology, ALS |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | July 2013 |
| End Date: | April 2015 |
Imaging Myelin Injury in Amyotrophic Lateral Sclerosis (ALS)
This is a pilot study to identify the degree of grey and white matter involvement in
patients with Amyotrophic Lateral Sclerosis (ALS) utilizing non-invasive techniques. The
imaging to be utilized will be the 7 Tesla (7T) magnetic resonance imaging (MRI) of the
brain. These results will be correlated to the ALS Functional Rating Scale - Revised
(ALSFRS-R) score to assess if any changes in MRI can be predictive in the disability of the
ALS patients at baseline and at 6 month intervals. The participants will be asked to return
every 6 months for a neurological examination, ALSFRS-R assessment, measurement of the vital
capacity and MRI as outlined above to monitor progression of the disease.
patients with Amyotrophic Lateral Sclerosis (ALS) utilizing non-invasive techniques. The
imaging to be utilized will be the 7 Tesla (7T) magnetic resonance imaging (MRI) of the
brain. These results will be correlated to the ALS Functional Rating Scale - Revised
(ALSFRS-R) score to assess if any changes in MRI can be predictive in the disability of the
ALS patients at baseline and at 6 month intervals. The participants will be asked to return
every 6 months for a neurological examination, ALSFRS-R assessment, measurement of the vital
capacity and MRI as outlined above to monitor progression of the disease.
Inclusion Criteria:
- Males and Females who are 18 - 80 years old.
- The participants will meet the standard diagnostic criteria for possible or probable
ALS (based on El Escorial criteria). They will have been diagnosed by a Johns Hopkins
Neurologist.
- Healthy controls will be recruited by their interest in assisting the ALS population.
Exclusion Criteria:
- Forced vital capacity less than 60 % of predicted value.
- Documented orthopnea on ALSFRS-R or otherwise unable to lie flat in an MRI scanner
for the duration of the study.
- Presence of pacemakers, aneurysm clips, shrapnel or otherwise disallowed implanted
metallic devices for obtaining an MRI scan.
- Pregnant or lactating females
- Glomerular filtration rate (GFR) less than 60
- History of: encephalitis, extensive white matter disease, intracranial hemorrhage,
cerebral palsy, allergy to dye and/or IV drug abuse.
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