Portable Oxygen Concentrator to Improve Quality of Life in Chronic Obstructive Pulmonary Disease

Evaluate subjects in an prospective observational study in which subjects will be screened
and administered scientifically validated questionnaires at study entry and during the
observation period at specified intervals to determine the affect of the Portable Oxygen
Concentrator on improvements in exercise capability, dyspnea and quality of life as primary
endpoints, utilizing the Baseline Dyspnea Index (BDI), Transitional Dyspnea Index (TDI), the
Chronic Respiratory Disease Questionnaire (CRQ) and six minute walk test (6MWT). The
secondary endpoints will be rate of exacerbations, sleep quality (reported as number of hours
sleep improvement; utilize Epworth Sleepiness Scale [ESS]), and health care utilization
(emergency room encounters, hospital admissions).

Inclusion Criteria:

- Primary diagnosis of chronic obstructive pulmonary disease (COPD)

- Clinically stable disease at the time of consent

- Current prescription of oxygen; with previous or current oximetry suggesting
desaturation at rest or during exercises (oxygen saturation ≤88% on at least one
occasion)

- Highest measured FEV1, 70% predicted; and

- Highest measured FEV1/FVC, 70% predicted

- Capable of giving informed consent

- Currently using oxygen system that is either a portable tank; liquid or other Portable
Oxygen Concentrator (POC)

- Mobility without a walker, cane or rollator

- Spo2 ≥ 92% on Portable Oxygen Concentrator (POC) at rest and activity

- Non-smoker at time of consent

Exclusion Criteria:

- Cardiovascular disease as defined in New York Heart Association Functional Class III

- Degenerative bone or joint disease that limits mobility and ability to perform
activities of daily living and/or exercise

- Current homeless persons

- Active drug/alcohol dependence

- Recent abuse history within the past two years

- Clinically unstable at the time of consent

- Currently a tobacco smoker