Early Levothyroxine Post Radioactive Iodine



Status:Recruiting
Conditions:Endocrine, Endocrine
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - 70
Updated:4/21/2016
Start Date:September 2013
End Date:December 2016
Contact:Jeanette Laugen
Email:laugen.jeanette@mayo.edu
Phone:507-255-8110

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Trial Summary
Trial Overview
Inclusion Criteria

Prevention of Overt Hypothyroidism Following Radioactive Iodine Therapy for Graves' Disease

The study will try to answer the question of whether early treatment with levothyroxine at 4
weeks after radioactive iodine for Graves'disease will prevent overt hypothyroidism (low
thyroid hormone levels).


Inclusion criteria target all adult patients (ages 18-70 years) with GD who will receive
RAI for treatment of GD. Patient with clinically manifest GO will be excluded from the
study. We will also exclude patients with recent (<1 yr.) history of arrhythmias or any
history of ventricular arrhythmias, those with preexistent cardiomyopathy, those with
malnutrition and those with psychiatric history that could get worse if patient remains
persistently hyperthyroid. Patients unlikely to return for the planned follow-up visits,
to comply with the blood drawing schedule and with the completion of the hypothyroid-HDQL
and TQS questionnaires will also be excluded.
We found this trial at
1
site
Mayo Clinic Rochester
200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Phone: 507-255-8345
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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