Sub-dissociative Ketamine for the Management of Acute Pediatric Pain
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 3 - 17 |
| Updated: | 7/5/2018 |
| Start Date: | December 2012 |
| End Date: | June 2015 |
The proposed trial is a prospective, double blinded, randomized control trial with the
primary aim of determining whether a single, sub-dissociative dose of ketamine will decrease
the total narcotic requirements of pediatric patients requiring intravenous analgesia in an
urban emergency department (ED) compared to a group of patients who receive morphine alone
for pain management. Patients are randomized to receive either a single bolus of ketamine
(0.3 mg/kg) or a single bolus of morphine (0.05mg/kg). All subsequent pain management will be
accomplished using morphine. Patient, family member, and research staff pain scores will be
recorded, until 3 hours post study medication administration. Family members are contacted
via telephone 24 hours post-ED discharge, and again at 7 days post-hospital discharge, for
evaluation via Post Hospitalization Behavior Questionnaire. Narcotic equivalents will be
calculated for up to 3 hours post study medication administration and compared between the
ketamine and morphine groups.
primary aim of determining whether a single, sub-dissociative dose of ketamine will decrease
the total narcotic requirements of pediatric patients requiring intravenous analgesia in an
urban emergency department (ED) compared to a group of patients who receive morphine alone
for pain management. Patients are randomized to receive either a single bolus of ketamine
(0.3 mg/kg) or a single bolus of morphine (0.05mg/kg). All subsequent pain management will be
accomplished using morphine. Patient, family member, and research staff pain scores will be
recorded, until 3 hours post study medication administration. Family members are contacted
via telephone 24 hours post-ED discharge, and again at 7 days post-hospital discharge, for
evaluation via Post Hospitalization Behavior Questionnaire. Narcotic equivalents will be
calculated for up to 3 hours post study medication administration and compared between the
ketamine and morphine groups.
Inclusion Criteria:
- Age: 3-17 years old
- Condition (medical or trauma) requiring opioid pain management per standard of care
- Need to establish an IV per standard of care
- Treating physician agrees to manage the patient's pain with morphine following
randomization.
Exclusion Criteria:
- Trauma Team Activation
- Known allergy to ketamine
- Family member unable/unavailable to provide informed consent
- When appropriate, patient unwilling to provide assent
- High suspicion of injury related to child abuse
- Patient and/or family member is non-English speaking
- Patient is incarcerated
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Regions Hospital Established in 1872, Regions Hospital is a private, not-for-profit organization. The hospital provides...
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