Study Comparing the Pharmacokinetics, Pharmacodynamics, and Safety of K-312 in Healthy Adult Volunteers

Inclusion Criteria:

- Subject provides written informed consent before any study-specific evaluation is
performed.

- Subject is a healthy adult male or a female of non-childbearing potential between the
ages of 18 and 45 years, inclusive.

- Subject has a body mass index of 18.5 to 32 kg/m2, inclusive.

Exclusion Criteria:

- Subject is a woman who is of childbearing potential or is breastfeeding.

- Subject has the presence of an active or recurring clinically significant
cardiovascular, pulmonary, renal, endocrine, hepatic, neurologic, psychiatric,
immunologic, hematologic, gastrointestinal, or metabolic disease requiring medical
treatment.