Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative Diseases
| Status: | Recruiting |
|---|---|
| Conditions: | Parkinsons Disease, Neurology, Neurology, Neurology, Neurology, Neurology, Multiple Sclerosis |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | December 2009 |
| Contact: | Carissa Tonkins |
| Email: | carissa.tonkins@carolinashealthcare.org |
| Phone: | 704-446-0836 |
The etiology of many neurodegenerative diseases is unknown. A few studies have suggested the
role of infection in the gastrointestinal tract in the etiology and pathogenesis of
neurological diseases such as idiopathic Parkinson. For example, infection with Helicobacter
pylori has been suggested to play a role in Parkinson disease. In addition, bacterial
pathogens such as spirochetes and bacterial products such as cyanobacterial toxins have been
speculated as the contributing factors in the development of amyotrophic lateral sclerosis
(ALS). The effect of microbial composition of the gut in the pathogenesis of ALS is
suspected. The difference in the bacterial profile of the gut has been documented in
diseases such as inflammatory bowel disease and obesity.
The goal of this IRB protocol is to create a human tissue bank and to obtain patients'
demographic information for future investigation of the role of bacterial pathogens and the
role of gut flora composition in the development of neurodegenerative diseases including but
not limited to ALS, Parkinson's disease, and multiple sclerosis.
role of infection in the gastrointestinal tract in the etiology and pathogenesis of
neurological diseases such as idiopathic Parkinson. For example, infection with Helicobacter
pylori has been suggested to play a role in Parkinson disease. In addition, bacterial
pathogens such as spirochetes and bacterial products such as cyanobacterial toxins have been
speculated as the contributing factors in the development of amyotrophic lateral sclerosis
(ALS). The effect of microbial composition of the gut in the pathogenesis of ALS is
suspected. The difference in the bacterial profile of the gut has been documented in
diseases such as inflammatory bowel disease and obesity.
The goal of this IRB protocol is to create a human tissue bank and to obtain patients'
demographic information for future investigation of the role of bacterial pathogens and the
role of gut flora composition in the development of neurodegenerative diseases including but
not limited to ALS, Parkinson's disease, and multiple sclerosis.
Inclusion Criteria:
- aged 18 years and older
- patients diagnosed with amyotrophic lateral sclerosis or other neurodegenerative
disease, and healthy controls
Exclusion Criteria:
- Subjects with acute bacterial infection of the GI tract
- Subjects on treatments with antibiotics or probiotics within 28 days prior to
sampling
We found this trial at
1
site
Click here to add this to my saved trials
