Hyperbaric Oxygen for Wagner II Diabetic Lower Extremity Ulcers
| Status: | Terminated |
|---|---|
| Conditions: | Other Indications, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | October 2013 |
| End Date: | August 2015 |
Hyperbaric Oxygen for Wagner II Diabetic Lower Extremity Ulcers: a Double-blind, Randomized,Controlled Clinical Trial.
The purpose of this proposed DoD study is to determine if hyperbaric oxygen therapy (HBOT)
plus standard wound care is more effective than standard wound care alone in the rate of
healing and prevention of major amputation (metatarsal and proximal) in Wagner grade 2
diabetic lower extremity ulcers.
plus standard wound care is more effective than standard wound care alone in the rate of
healing and prevention of major amputation (metatarsal and proximal) in Wagner grade 2
diabetic lower extremity ulcers.
Inclusion Criteria:
1. Age equal to or greater than 18.
2. Type 1 or 2 diabetes mellitus.
3. Wagner Grade 2 wound for at least 4 weeks. A diagnosis of a Wagner Grade 2 wound
necessitates a persistent wound of 4 weeks (5).
4. DoD Beneficiary.
Exclusion Criteria:
1. Impending/urgent amputation due to ongoing or exacerbated infection.
2. Exposed bone or deep structures.
3. Severe depression.
4. Claustrophobia.
5. Seizure disorder.
6. Uncontrolled asthma/severe COPD with pCO2 > 45 mmHg on arterial blood gas.
7. Grade 4 congestive heart failure.
8. Unstable angina.
9. Chronic/acute otitis media/sinusitis.
10. Major tympanic membrane trauma.
11. Prior chemotherapy with Bleomycin and evidence of deterioration in diffusing capacity
after a single hyperbaric oxygen exposure.
12. Candidates for vascular surgery/angioplasty/stenting or patients with major large
vessel disease. These patients could have peripheral vascular disease of such
severity that hyperbaric treatment would not improve their condition.
13. Vascular surgery/angioplasty within the last 3 months. This exclusion controls for
improvements to a patients vasculature and perfusion that occur within 1-2 months
after vascular surgery/angioplasty. This will ensure that any perfusion changes to
the patient's diabetic wound ulcer area recorded during the study are a result of
hyperbaric therapy instead of recent vascular procedures.
14. Women who are breast feeding or of childbearing potential.
15. Dementia or mental disability rendering the potential subject incapable of following
instructions or consenting to treatment.
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