Study of Lu AE58054 in Patients With Mild - Moderate Alzheimer's Disease Treated With Donepezil



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - Any
Updated:6/1/2017
Start Date:October 2013
End Date:July 2016

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Randomised, Double-blind, Parallel-group, Placebo-controlled, Fixed-dose Study of Lu AE58054 in Patients With Mild - Moderate Alzheimer's Disease Treated With Donepezil

To establish efficacy of Lu AE58054 as adjunctive therapy to donepezil for symptomatic
treatment of patients with mild-to-moderate Alzheimer's disease (AD).


Inclusion Criteria:

- The patient has a knowledgeable and reliable caregiver.

- The patient is an outpatient.

- The patient has probable AD.

- The patient has mild to moderate AD.

- Stable treatment with donepezil.

- The patient, if a woman, must have had her last natural menstruation ≥24 months prior
to baseline, OR be surgically sterile.

- The patient, if a man, agrees to protocol-defined use of effective contraception if
his female partner is of childbearing potential, OR must have been surgically
sterilised prior to the screening visit.

Exclusion Criteria:

- The patient has evidence of any clinically significant neurodegenerative disease, or
other serious neurological disorders other than AD.

- The patient has a Diagnostic and Statistical Manual of Mental Disorders, 4th edition,
Text Revision (DSM-IV-TR) Axis I disorder other than AD.

- The patient has evidence of clinically significant disease.

- The patient's donepezil therapy is likely to be interrupted or discontinued during
the study.

- The patient is currently receiving memantine or has taken memantine within 2 months
prior to screening.

Other inclusion and exclusion criteria may apply.
We found this trial at
47
sites
Staten Island, New York
469
mi
from 43215
Staten Island, NY
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Albany, New York
515
mi
from 43215
Albany, NY
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Amherst, New York 14226
301
mi
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Amherst, NY
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Arlington, Virginia
324
mi
from 43215
Arlington, VA
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Atlanta, Georgia 30322
432
mi
from 43215
Atlanta, GA
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Birmingham, Alabama 35294
492
mi
from 43215
Birmingham, AL
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Boca Raton, Florida
954
mi
from 43215
Boca Raton, FL
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Bradenton, Florida 34205
864
mi
from 43215
Bradenton, FL
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Brooksville, Florida 34601
789
mi
from 43215
Brooksville, FL
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Buenos Aires,
5386
mi
from 43215
Buenos Aires,
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Centerville, Ohio 45459
65
mi
from 43215
Centerville, OH
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Chicago, Illinois 60612
277
mi
from 43215
Chicago, IL
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Columbus, Ohio 43221
1
mi
from 43215
Columbus, OH
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Denver, Colorado
1162
mi
from 43215
Denver, CO
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Edmond, Oklahoma
842
mi
from 43215
Edmond, OK
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41 Flowood Drive
Flowood, Mississippi 39232
662
mi
from 43215
Flowood, MS
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Freeport, Maine 04032
715
mi
from 43215
Freeport, ME
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Glendale, California
1970
mi
from 43215
Glendale, CA
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Imperial, California 92251
1863
mi
from 43215
Imperial, CA
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Indianapolis, Indiana 46202
167
mi
from 43215
Indianapolis, IN
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Jenkintown, Pennsylvania
417
mi
from 43215
Jenkintown, PA
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Joliet, Illinois
285
mi
from 43215
Joliet, IL
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Kailua, Hawaii
4493
mi
from 43215
Kailua, HI
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Kalamazoo, Michigan 49048
208
mi
from 43215
Kalamazoo, MI
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La Jolla, California
1957
mi
from 43215
La Jolla, CA
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Little Rock, Arkansas 72205
625
mi
from 43215
Little Rock, AR
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Long Beach, California
1976
mi
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Long Beach, CA
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Los Angeles, California 90660
1966
mi
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Los Angeles, CA
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Madison, Wisconsin 53705
395
mi
from 43215
Madison, WI
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Manhasset, New York 11030
493
mi
from 43215
Manhasset, NY
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Milwaukee, Wisconsin 53226
329
mi
from 43215
Milwaukee, WI
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New York, New York 10016
478
mi
from 43215
New York, NY
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New York, New York 10032
481
mi
from 43215
New York, NY
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New York, New York
477
mi
from 43215
New York, NY
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Newton, Massachusetts
635
mi
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Newton, MA
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Orangeburg, New York
482
mi
from 43215
Orangeburg, NY
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Orlando, Florida 32806
797
mi
from 43215
Orlando, FL
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Phoenix, Arizona 85006
1662
mi
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Phoenix, AZ
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Port Charlotte, Florida 33980
898
mi
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Port Charlotte, FL
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Portland, Oregon
2026
mi
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Portland, OR
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Princeton, New Jersey
441
mi
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Princeton, NJ
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Saint Louis, Missouri
394
mi
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Saint Louis, MO
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San Francisco, California
2107
mi
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San Francisco, CA
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Santa Ana, California 92705
1960
mi
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Santa Ana, CA
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Toms River, New Jersey 08755
466
mi
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Toms River, NJ
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Toms River, New Jersey
467
mi
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Toms River, NJ
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West Palm Beach, Florida 33407
931
mi
from 43215
West Palm Beach, FL
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