Emotional Prosody Treatment in Parkinson's



Status:Recruiting
Conditions:Parkinsons Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:45 - 85
Updated:5/7/2016
Start Date:October 2013
End Date:September 2016
Contact:Susan A Leon, PhD
Email:susan.leon@va.gov

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Treatment of Emotional Prosodic Disorders in Parkinson's Disease

This study investigates a treatment protocol which holds the potential to significantly
improve communication and quality of life for individuals affected by Parkinson's disease
(PD). Disorders of emotional communication are widely reported in PD and can negatively
impact quality of life by increasing social isolation and decreasing independence.
Individuals with emotional prosodic communication disorders are often perceived as depressed
or unconcerned about others. This seeming negativity can cause difficulties in
relationships, and increased feelings of stress and burden in caregivers which may result in
earlier placement in an institutional care setting. This innovative treatment program could
improve care for individuals with PD, as well as other individuals who may be affected by
disorders of emotional prosodic communication (e.g., stroke or traumatic brain injury).

Individuals with Parkinson's disease (PD) present with a variety of motor symptoms including
resting tremor, difficulty initiating movement/slowed movements, and rigidity. While these
motor signs and symptoms are the hallmark features, individuals with PD also often
demonstrate changes in communication ability, with an estimated prevalence of 89 percent of
all individuals with PD being affected. These disorders of communication have been reported
by individuals with PD and their caregivers to be one of the most difficult aspects of
living with this disorder.

The most commonly diagnosed communicative disorder in PD is hypokinetic dysarthria which can
result in changes in prosody, respiratory control, voice quality, and articulation. Of
these, the disorders in prosody have been judged to be the most prominent deficit. Prosody
includes the pitch, loudness, and rate with which speech utterances are produced and is used
to communicate emotional connotation (e.g. angry versus sad). Impairments in speech prosody
reduce the ability to communicate emotional feelings or intentions as well as reducing the
intelligibility of the spoken message. While pharmacological treatments have been shown to
be effective in improving motor function, these medications have not been shown to greatly
mitigate speech production disorders including prosody, suggesting that therapies other than
dopaminergic agents are needed to address prosody deficits in PD. Despite a negative impact
on quality of life and reduced independence of individuals affected by emotional prosodic
disorders, no published studies are available testing therapies to improve production of
emotional prosody in PD.

The primary goal of this proposal is to compare a treatment protocol shown to be effective
in treating emotional prosodic deficit in stroke and TBI (Leon et al., 2005; Rosenbek et
al., 2006) to a standard clinical treatment for prosody deficit that does not target the
emotional aspect of the disorder in individuals with PD. The experimental treatment targets
increased pitch and loudness variability, and control of speech rate, the core
characteristics of prosodic insufficiency in PD, but with an emphasis on the emotional
component of the disorder. The primary aims of the study are to determine treatment effect
size by measuring the difference of the experimental protocol versus standard clinical care
on prosodic deficit in individuals with PD via changes in acoustic and perceptual measures,
as well as provide psychometric validation of test-retest reliability of the outcome
measures.

Inclusion Criteria:

- Experimental subjects must meet the Brain Bank criteria (Gibb & Lees, 1988) for
idiopathic PD.

- All participants must:

- be between the ages of 45 and 85

- have at least a sixth grade education

- fluent in English

- The investigators will obtain information about participant's Parkinson's disease
history from medical records including:

- age at onset

- current age

- gender

- handedness

- level of education

- side of the body initially affected

- information regarding subsequent clinical progression

- medications

- most recent Unified Parkinson Disease Rating Scale (UPDRS) scores

- Hoehn and Yahr (H&Y) (Hoehn & Yahr, 1967) scores

- The investigators will include subjects with H&Y Stages between 2 and 4

- Participants must be judged as having at least a mild level of affective prosodic
deficit in pretreatment testing

Exclusion Criteria:

- Individuals will be excluded with other forms of Parkinsonism such as:

- multiple systems atrophy

- Lewy body dementia

- progressive supranuclear palsy

- Other exclusionary criteria will be:

- co-existing dementia (as indicated by score on Montreal Cognitive Assessment of
below 26)

- neurological disease other than idiopathic PD

- major depression

- any other psychiatric illness

- chronic medical and neurological diseases other than PD (e.g., cardiac failure,
renal disease, hepatic failure, stroke, or severe sensory deficits such as
deafness or blindness (corrected visual acuity less than 20/50).
We found this trial at
1
site
Gainesville, Florida 32608
Principal Investigator: Susan A Leon, PhD
Phone: 352-376-1611
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Gainesville, FL
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