The Effect of Whey Protein Supplementation on Vascular and Cognitive Function in Older Adults

The "hardening of the arteries" observed with aging raises blood pressure and contributes to
poor brain blood flow and loss of cognitive function (i.e. attention, memory, solving
problems, making decisions). Cognition is the most important determinant of overall health
status, quality of life, functional ability and independence in older adulthood.
Nutraceutical strategies have received considerable attention as they may improve
cardiovascular health with far fewer side effects compared to drugs. In this regard, dairy
products are particularly attractive. Higher dairy consumption is associated with lower blood
pressure and improved memory in adults. Milk proteins have natural blood pressure lowering
effects. Studies conducted in animals have demonstrated that whey protein (a component of
milk protein) may also increase artery elasticity. This is important given the strong
association between artery elasticity, brain blood flow, and risk for cognitive decline.

The investigators propose to conduct a randomized double-blind placebo controlled study
comparing the effects of whey protein supplementation or carbohydrate placebo on measures of
artery elasticity, brain blood flow, and cognitive function in older adults. Whey protein may
be a novel dietary therapy to improve both artery health and brain health in older adults.