Blood Collection for Research Related to Certain Diseases Involving Blood Vessels

Status:	Archived
Conditions:	Hematology
Therapuetic Areas:	Hematology
Healthy:	No
Age Range:	Any
Updated:	7/1/2011

Collection of Blood From Volunteers and Patients for Studies of Endothelial Function and Systemic Inflammation

This study will collect blood from healthy volunteers and from patients with certain
inflammatory diseases involving blood vessels. The blood will be used to study genes,
proteins and the lining cells of blood vessels in patients with inflammatory diseases
involving blood vessels. The blood will also be used for developing new tests to study
these diseases.

Normal volunteers and patients with the following diseases or conditions may be eligible for
this study:

- Sickle cell disease

- Arteriosclerosis (hardening of the arteries)

- Hemolytic diseases (diseases involving destruction of red blood cells)

- Sepsis (infection of the blood or other tissues)

- Other diseases involving inflammation and the endothelium (lining cells of the heart,
blood and lymph vessels, and cavities of the body)

Participants must be at least 5 years old.

All participants will give a medical history and have a physical examination. Sickle cell
patients and healthy volunteers will have tests to determine if they have sickle cell
disease, sickle cell trait, or beta-thalassemia. All participants will donate blood from
either a vein or an artery. To collect blood from a vein, a needle is placed in a vein in
the bend of the elbow and blood is drawn into several syringes or tubes. To collect blood
from an artery, a needle is placed in an artery in the arm above the elbow or in an artery
on the wrist and blood is drawn into several syringes or tubes. (Arterial blood will be
drawn only from participants 18 years of age or older.) No more than 450 ml (about 1 pint)
of blood will be collected from any donor over an 8-week period.

...

We are evaluating the role of nitric oxide, inflammatory mediators, and endothelial function
in inflammatory diseases that involve the blood vessels, such as sickle cell disease,
coronary artery disease, pulmonary vascular or advanced lung disease, malaria, and sepsis.
The collection of human blood from both patients and healthy volunteers is necessary for the
development of laboratory assays required for these studies. This protocol defines in
general terms the purposes for which blood will be collected by members of the Clinical
Center Critical Care Medicine Department, Laboratory of Chemical Biology, NIDDK, and
Pulmonary and Vascular Medicine Branch, NHLBI, and the conditions under which sampling of
blood collection will be performed. We will also be collecting blood from children at
Children's National Medical Center for a collaborative study of fetal hemoglobin and from
INOVA Fairfax Hospital for a collaborative study of pulmonary vascular or advanced lung
disease.

We found this trial at

sites

National Institutes of Health Clinical Center

9000 Rockville Pike
Bethesda, Maryland 20892

301-496-2563