Effects of Smoked Marijuana on Risk Taking and Decision Making Tasks

Cannabis abuse and dependence are the most prevalent drug use disorders in the United States
(Compton et al., 2004), yet little is known about the factors contributing to successful
marijuana treatment. Previously, we have shown that cognitive impairments in patients treated
for substance disorders are associated with premature treatment dropout. However, little is
known about whether such impairments are the result of drug use per se. The objective of this
within-subject study is to determine whether decision-making and risk-taking are affected by
acute cannabis intoxication. The Balloon Analogue Risk Task (BART; Lejuez et al. 2002)
assesses decision making in a context of increasing risk, and the Iowa Gambling Task (IGT;
Bechara et al. 1994) tests the ability to balance immediate rewards against long-term
negative consequences; both tasks have strong face validity for evaluating cognitive deficits
that may contribute to poor treatment outcome. Research volunteers will be current marijuana
smokers. Each will participate in three, 4-hour outpatient sessions in the Substance Use
Research Center (SURC) in the Division of Substance Abuse at NYSPI. They will smoke a
different strength marijuana cigarette (0.0, 1.98, 3.9% THC) in each session in
counter-balanced order. After baseline data have been collected (risk taking and decision
making behaviors, heart rate, blood pressure, mood scales, exhaled carbon monoxide),
participants will take 3-6 puffs, 5 seconds in duration, from a National Institute on Drug
Abuse (NIDA) marijuana cigarette. After smoking, we will repeatedly re-assess risk taking and
decision making abilities with the BART and IGT. We will also measure subjective mood
ratings, heart rate and blood pressure repeatedly for 180 minutes following smoking. This
study is the first controlled investigation of the effects of smoked marijuana on both risk
taking and decision making tasks. The data obtained will be used to guide treatment
development for marijuana use disorders.

Inclusion Criteria:

- Current marijuana use

- 21-45 years of age

- Practicing an effective form of birth control

- Not seeking treatment for marijuana use

Exclusion Criteria:

- Current, repeated illicit drug use other than marijuana

- Presence of significant medical illness (e.g., diabetes, cardiovascular disease,
hypertension)

- Laboratory tests outside normal limits that are clinically unacceptable to the study
physician (BP > 140/90; hematocrit < 34 for women, < 36 for men)

- Significant adverse reaction to marijuana

- Current parole or probation

- Pregnancy or current lactation

- Recent history of significant violent behavior

- Major current Axis I psychopathology (e.g., mood disorder with functional impairment
or suicide risk, anxiety disorder, schizophrenia

- History of heart disease

- Current use of any over-the-counter or prescription medication from which the
volunteer cannot be withdrawn