A High Density EEG Comparison of Sleep Patterns in Insomnia
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 12/21/2017 |
| Start Date: | October 2013 |
| End Date: | September 2017 |
A High Density EEG Comparison of Sleep, Sleep Initiation, and Arousal Patterns in Insomnia Patients and Normal Controls
Insomnia, defined as a subjective report of difficulty initiating sleep, maintaining sleep,
and/or non-restorative sleep, leads to significant daytime dysfunction and increased health
risks. A commonly held hypothesis is that insomnia is caused by a state of hyperarousal, but
the neurobiological mechanisms of hyperarousal in insomnia are poorly understood, in part
because of limitations in our ability to image the brain during normal human sleep with
sufficient temporal resolution. Furthermore, the efficacy of insomnia treatment is judged by
subjective report of the patient and demonstration of changes in sleep latency and/or sleep
amount which are generally small in magnitude; there are currently no data to demonstrate
that insomnia treatments correct any functional abnormalities in the sleep process that
likely contribute to neurobehavioral abnormalities and health risks. The goals of the
proposed study are to use high density EEG to define abnormalities in specific aspects of
sleep in insomnia patients compared to healthy sleeping control subjects to define biomarkers
that will both increase our understanding of the pathophysiology of insomnia as well as
provide targets to assess treatments for insomnia.
and/or non-restorative sleep, leads to significant daytime dysfunction and increased health
risks. A commonly held hypothesis is that insomnia is caused by a state of hyperarousal, but
the neurobiological mechanisms of hyperarousal in insomnia are poorly understood, in part
because of limitations in our ability to image the brain during normal human sleep with
sufficient temporal resolution. Furthermore, the efficacy of insomnia treatment is judged by
subjective report of the patient and demonstration of changes in sleep latency and/or sleep
amount which are generally small in magnitude; there are currently no data to demonstrate
that insomnia treatments correct any functional abnormalities in the sleep process that
likely contribute to neurobehavioral abnormalities and health risks. The goals of the
proposed study are to use high density EEG to define abnormalities in specific aspects of
sleep in insomnia patients compared to healthy sleeping control subjects to define biomarkers
that will both increase our understanding of the pathophysiology of insomnia as well as
provide targets to assess treatments for insomnia.
Inclusion Criteria:
- 18-45 years old
- English speaking, reading, and writing
- For control subjects: Insomnia Severity Index (ISI) less than or equal to 6 and does
not meet criteria for insomnia
- For insomnia subjects: ISI greater than or equal to 7, meets criteria for insomnia,
and reports insomnia symptoms for at least 6 months
Exclusion Criteria:
- Imminent danger to self or others
- Clinical diagnosis of dementia
- Active Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV Axis I disorder
or alcohol or drug dependence or abuse
- Other sleep disorders aside from insomnia
- History of significant head trauma or loss of consciousness over 30 minutes
- Regular use of psychotropic medications in past 4 weeks
- Regular tobacco use
- Drinking more than 3 caffeinated beverages per day
- Significant neurological or medical illness
- Pregnant, less than 6 months post-partum, or planning to become pregnant during the
study
- Left-handedness
- Body Mass Index (BMI) greater than 40
- Apnea Hypopnea Index (AHI) greater than 10 on Apnea Link
- Mini mental status exam score less than 27
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