Lorcaserin for Weight Loss Management in Patients on Antipsychotics: A Pilot Study



Status:Recruiting
Conditions:Obesity Weight Loss
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - 65
Updated:4/2/2016
Start Date:January 2014
Contact:Susan Shakib, Pharm.D.
Email:susan.shakib@va.gov
Phone:562-826-8000

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Trial Summary
Trial Overview
Inclusion Criteria
The purpose of this study is to determine whether lorcaserin is effective for weight
reduction in patients with weight gain as a result of antipsychotic medications.


INCLUSION CRITERIA:

- Patients currently on atypical antipsychotics

- The patient's BMI is greater than or equal to 30 kg/m2 OR the patient's BMI is
greater than or equal to 27 kg/m2 in the presence of at least one weight-related
co-morbidity such as hypertension, type 2 diabetes mellitus, dyslipidemia, metabolic
syndrome, obstructive sleep apnea, or degenerative joint disease such as
osteoarthritis.

- Patient agreeable to follow up with provider at the scheduled appointments at week 1,
week 2, week 4, week 8, week 12 and week 16 after initiation of medication.

EXCLUSION CRITERIA:

- Pregnancy in women or breastfeeding

- The patient has greater than mild aortic valve regurgitation, or moderate to greater
mitral valve regurgitation

- Known hypersensitivity to lorcaserin

- The patient is taking another weight loss medication concurrently

- Dementia

- Age less than 18 or greater than 65

- No recent substance abuse within 3 months

- No suicidal ideation within 3 months

- Unable to give informed consent, unless patient is conserved, then the conservator
can provide informed consent
We found this trial at
1
site
VA Long Beach
Long Beach, California 90822
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from
Long Beach, CA
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