Can Ondansetron Prevent Neonatal Abstinence Syndrome (NAS) in Babies Born to Narcotic-dependent Women
| Status: | Recruiting |
|---|---|
| Conditions: | Psychiatric, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | Any - 45 |
| Updated: | 9/8/2018 |
| Start Date: | September 9, 2014 |
| End Date: | May 31, 2021 |
| Contact: | Carol A Cohane, RN |
| Email: | cohane@stanford.edu |
| Phone: | 650-736-8231 |
AIM 2- Prevention of Neonatal Abstinence Syndrome
The Investigators hope to learn if they can prevent or lessen the symptoms of neonatal
abstinence syndrome (NAS) in babies born to narcotic-dependent mothers by using the drug
ondansetron in the mothers prior to delivery and their babies after delivery.
The study is a randomized, double-blind, placebo-controlled study with one half the
mother-baby pairs to receive ondansetron and the other half of the mother-baby pairs to
receive placebo. The pregnant narcotic-dependent mothers will receive an intravenous dose of
study medication prior to delivery; the neonates, after their birth, will receive the same
study medication the mother received every 24 hours for up to 5 days.
The Investigators will follow up with the mother-baby pairs for 10 days after study drug has
stopped and one last follow up, about 30 days after stopping study drug, to learn if the baby
had any symptoms of NAS in that time period.
abstinence syndrome (NAS) in babies born to narcotic-dependent mothers by using the drug
ondansetron in the mothers prior to delivery and their babies after delivery.
The study is a randomized, double-blind, placebo-controlled study with one half the
mother-baby pairs to receive ondansetron and the other half of the mother-baby pairs to
receive placebo. The pregnant narcotic-dependent mothers will receive an intravenous dose of
study medication prior to delivery; the neonates, after their birth, will receive the same
study medication the mother received every 24 hours for up to 5 days.
The Investigators will follow up with the mother-baby pairs for 10 days after study drug has
stopped and one last follow up, about 30 days after stopping study drug, to learn if the baby
had any symptoms of NAS in that time period.
All neonates will have a screening 12-lead EKG prior to their first dose of study medication
to determine if QTc prolongation is present. A repeat 12-lead EKG will be done after each
dose of study medication, approximately 2-5 hours post dose; if a neonate has prolonged QTc
the study drug will be stopped.
Investigators may obtain up to 9 pharmacokinetic (PK) blood samples from the neonates over 5
days when standard of care blood samples are drawn. These samples will consist of 1 to 2
drops of blood collected on filter paper and sent to Stanford for PK analysis.
The modified Finnegan scoring system will be used to evaluate neonates for symptoms of NAS at
each site and it is considered standard-of-care for babies at risk of NAS. Morphine will be
the first treatment choice before other treatment medication choices (opioid or non-opioid)
for NAS symptoms. Each site involved has established guidelines for starting, advancing and
weaning treatment for NAS. Any medication used to treat NAS will be recorded.
Interim analysis: will be performed after the first 20 pregnant women and their neonates have
been enrolled and dosed with study drug. (Interim Analysis was done on first 21 mother/baby
pairs in May 2016).
To protect the confidentiality of the patients (study subjects), the lead site, Stanford
University, received a Certificate of Confidentiality from the NIH.
to determine if QTc prolongation is present. A repeat 12-lead EKG will be done after each
dose of study medication, approximately 2-5 hours post dose; if a neonate has prolonged QTc
the study drug will be stopped.
Investigators may obtain up to 9 pharmacokinetic (PK) blood samples from the neonates over 5
days when standard of care blood samples are drawn. These samples will consist of 1 to 2
drops of blood collected on filter paper and sent to Stanford for PK analysis.
The modified Finnegan scoring system will be used to evaluate neonates for symptoms of NAS at
each site and it is considered standard-of-care for babies at risk of NAS. Morphine will be
the first treatment choice before other treatment medication choices (opioid or non-opioid)
for NAS symptoms. Each site involved has established guidelines for starting, advancing and
weaning treatment for NAS. Any medication used to treat NAS will be recorded.
Interim analysis: will be performed after the first 20 pregnant women and their neonates have
been enrolled and dosed with study drug. (Interim Analysis was done on first 21 mother/baby
pairs in May 2016).
To protect the confidentiality of the patients (study subjects), the lead site, Stanford
University, received a Certificate of Confidentiality from the NIH.
Inclusion Criteria:
- adult female, opioid-dependent for at least 3 weeks prior to delivery.
- adult female, otherwise healthy.
- adult female, age 18-45 years inclusive.
- adult female, signed consent to participate for self and neonate (maternal subject may
decide not to receive the study drug but her neonate can still be included in the
study).
- neonate, gestational age 37 weeks through 41 weeks and 6 days at birth.
- neonate, corrected QT interval (QTc) from 12-lead electrocardiogram (ECG) less than
480 milliseconds (ms).
Exclusion Criteria:
- adult female, any condition that, in the opinion of the investigator, would compromise
the health of the participant (both mother and fetus) or the integrity of the data.
- adult female, known allergy to study drug (ondansetron).
- adult female, screening 12-lead ECG, if done, showing prolonged QTc will stop the
mother from receiving any study drug but her neonate can still be included in the
study.
- adult female, not dependent on opioids for at least 3 weeks prior to delivery.
- adult female, generally not healthy.
- adult female, age 17 years or less or 46 years of age and older.
- adult female and neonate, the maternal ingestion or administration of ondansetron
within 24 hours prior to delivery, for reasons other than study purposes, will exclude
the mother and the neonate.
- neonate, preterm or post-term gestational age at delivery.
- neonate, QTc showing results greater than or equal to 480ms on any 12-lead ECG post
delivery will stop the dosing of the study drug, but safety follow up will be done if
the mother or baby received at least one dose of study drug.
We found this trial at
1
site
300 Pasteur Dr
Stanford, California 94305
Stanford, California 94305
(650) 723-4000
Principal Investigator: David R Drover, MD
Stanford Univ Med Ctr The Medical Center is uniquely advantaged by its location on the...
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