A Study of LY3127760 in Healthy Participants

Inclusion Criteria:

- Overtly healthy males or females as determined by medical history and physical
examination

- Male participants agree to use a reliable method of birth control during the study and
3 months following the last dose of the investigational product

- Female participants not of child-bearing potential

- Have a body mass index of 18.5 to 32 kilograms per square meter (kg/m^2) inclusive

- Are normotensive (defined as supine systolic blood pressure (BP) less than 140
millimeters of mercury [mm Hg] and diastolic BP less than 90 mm Hg) without use of any
antihypertensives

Exclusion Criteria:

- Have known allergies to LY3127760, related compounds or any components of the
formulation, celecoxib or sulfonamides, or history of significant atopy. Participants
with known aspirin allergy or allergic reactions to nonsteroidal anti-inflammatory
drugs (NSAIDs) should also be excluded

- Have any current or prior history of a significant gastrointestinal illness such as
peptic ulcer disease, gastrointestinal (GI) bleeding, chronic gastritis, inflammatory
bowel disease or chronic diarrhea

- Have evidence of other chronic liver disease, including but not limited to chronic
alcoholic disease, nonalcoholic steatohepatitis, recent history (within 3 months of
screening) of acute viral hepatitis or chronic autoimmune hepatitis

- Have used any NSAIDs, celecoxib, aspirin or acetaminophen (at doses greater than 1
gram per day), anticoagulants or antiplatelet agents within 14 days of admission

Part 2 and Part 3 only

- Have 1 plus pretrial pitting edema or 2 plus ankle or pedal edema