Effect of Transdermal Magnesium Chloride on Quality of Life in Patients With Fibromyalgia
| Status: | Completed |
|---|---|
| Conditions: | Fibromyalgia, Pain |
| Therapuetic Areas: | Musculoskeletal, Rheumatology |
| Healthy: | No |
| Age Range: | 40 - 70 |
| Updated: | 3/1/2014 |
| Start Date: | October 2013 |
| End Date: | October 2014 |
| Contact: | Dietlind L. Wahner-Roedler, MD |
| Email: | wahnerroedler.dietlind@mayo.edu |
| Phone: | 507-284-2269 |
Effect of Transdermal Magnesium Chloride on Quality of Life in Patients With Fibromyalgia - A Pilot Study
In this pilot study we propose to gather preliminary data on whether transdermal magnesium
chloride can improve quality of life in patients with fibromyalgia. Forty women with
fibromyalgia will be enrolled in this study. Participants will be asked to apply a topical
solution of magnesium chloride on their extremities 3 times daily for 28 consecutive days.
Three questionnaires measuring quality of life will be administered at baseline, at 2 weeks,
and at 4 weeks (end of study).
chloride can improve quality of life in patients with fibromyalgia. Forty women with
fibromyalgia will be enrolled in this study. Participants will be asked to apply a topical
solution of magnesium chloride on their extremities 3 times daily for 28 consecutive days.
Three questionnaires measuring quality of life will be administered at baseline, at 2 weeks,
and at 4 weeks (end of study).
Fibromyalgia is a chronic pain syndrome with no known etiology. Fibromyalgia is generally
diagnosed in patients reporting widespread musculoskeletal pain, and tenderness. In addition
to widespread pain, fibromyalgia is also characterized by chronic fatigue, depression, sleep
disturbances, and poor concentration. It has been reported that approximately 3.5% of women
and 0.5% of men in the United States suffer from fibromyalgia. While the primary cause of
fibromyalgia remains unclear, a growing body of evidence indicates that the widespread pain
associated with fibromyalgia is due to abnormalities in the central nervous system. The pain
threshold, both mechanical and thermal, in fibromyalgia sufferers are lowered such that it
requires a lesser than normal stimulus to elicit pain.
Recent reports suggest that fibromyalgia is an oxidative stress disorder and deficiency in
trace elements and antioxidants play an important role in the development of fibromyalgia.
Magnesium is a trace element that is important for many metabolic functions. It affects cell
membrane permeability and electrical activity. The similarity in the clinical symptoms of
fibromyalgia and magnesium deficiency along with the histopathological findings of tender
points (such as hypoxia and adenosine triphosphate deficiency) raises the possibility that
magnesium may play a role in fibromyalgia etiopathogenesis.
In this pilot study we propose to explore the feasibility and ease of 2 times a day
application of a topical solution to the arms and legs. We will also gather preliminary data
on whether transdermal magnesium chloride can improve quality of life in women with
fibromyalgia.
diagnosed in patients reporting widespread musculoskeletal pain, and tenderness. In addition
to widespread pain, fibromyalgia is also characterized by chronic fatigue, depression, sleep
disturbances, and poor concentration. It has been reported that approximately 3.5% of women
and 0.5% of men in the United States suffer from fibromyalgia. While the primary cause of
fibromyalgia remains unclear, a growing body of evidence indicates that the widespread pain
associated with fibromyalgia is due to abnormalities in the central nervous system. The pain
threshold, both mechanical and thermal, in fibromyalgia sufferers are lowered such that it
requires a lesser than normal stimulus to elicit pain.
Recent reports suggest that fibromyalgia is an oxidative stress disorder and deficiency in
trace elements and antioxidants play an important role in the development of fibromyalgia.
Magnesium is a trace element that is important for many metabolic functions. It affects cell
membrane permeability and electrical activity. The similarity in the clinical symptoms of
fibromyalgia and magnesium deficiency along with the histopathological findings of tender
points (such as hypoxia and adenosine triphosphate deficiency) raises the possibility that
magnesium may play a role in fibromyalgia etiopathogenesis.
In this pilot study we propose to explore the feasibility and ease of 2 times a day
application of a topical solution to the arms and legs. We will also gather preliminary data
on whether transdermal magnesium chloride can improve quality of life in women with
fibromyalgia.
Inclusion Criteria:
- Patients diagnosed with fibromyalgia at Mayo Clinic Rochester's Fibromyalgia Clinic
- Postmenopausal women (no menstrual period for 1 year or more)
- Women age 40-70 that have had a hysterectomy
- Willing to travel to Mayo Clinic Rochester for the initial instruction visit
- Able to apply the transdermal magnesium chloride as directed
- Able to complete the questionnaires and daily diary
- Able and willing to give informed consent
- Able to speak, write and understand English
Exclusion Criteria:
- Patients on dialysis
- Individuals who decline to participate in the study
- Diagnoses of bipolar disorder, schizophrenia or dementia
- Patients with myasthenia gravis and myasthenic syndromes
- Patients on magnesium supplements
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