Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:8/2/2018
Start Date:October 29, 2013
End Date:July 10, 2017

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 3 Double-blind, Randomized, Placebo-controlled, Parallel-group Study To Assess The Efficacy, Long-term Safety And Tolerability Of Pf-04950615 In Subjects With Primary Hyperlipidemia Or Mixed Dyslipidemia At Risk Of Cardiovascular Events

This study is a multicenter, randomized study in subjects with high cholesterol receiving
highly effective statins to assess the efficacy, safety and tolerability of Bococizumab
(PF-04950615;RN316) to lower LDL-C.


Inclusion Criteria:

- Treated with a statin.

- Fasting LDL-C > 70 mg/dL and triglyceride <=400 mg/dL.

- High or very high risk of incurring a cardiovascular event.

Exclusion Criteria:

- Pregnant or breastfeeding females.

- Cardiovascular or cerebrovascular event of procedures during the past 30 days.

- Congestive heart failure NYHA class IV.

- Poorly controlled hypertension.
We found this trial at
156
sites
East Coast Institute for Research, LLC at Northeast Florida Endocrine & Diabetes Associates
Jacksonville, Florida 32204
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Avail Clinical Research
860 Peachwood Drive
DeLand, Florida 32720
(386) 740-0770
Site Overview Avail Clinical Research is a renowned and experienced clinical research site conducting Phase...
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Upstate Pharmaceutical Research
30 Pointe Circle
Greenville, South Carolina 29615
(864)255-3540
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AGA Clinical Trials
900 W 49th St # 430
Hialeah, Florida 33012
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Baylor College of Medicine
1200 Moursund Street
Houston, Texas 77030
(713) 798-4951
Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
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International Research Associates
8200 SW 117th Ave # 210
Miami, Florida 33183
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Radiant Research, Inc.
Akron, Ohio 44311
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Albany Medical College Division of Community Endocrinology
Albany, New York 12206
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KRK Medical Research
Arlington, Texas 76012
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North Alabama Research Center
Athens, Alabama 35811
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Ernest L. Hendrix, MD, PC
108 Sanders Street
Athens, Alabama 35611
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Atlanta Diabetes Associates
Atlanta, Georgia 30309
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ACRC - Cardiology
Atlantis, Florida 33462
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Care Clinical Research Corporation
Banning, California 92220
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Southern Maine Health Care
Biddeford, Maine 04005
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Alabama Internal Medicine, PC
Birmingham, Alabama 35235
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Drug Shipment and Study Conducted at Address: University of Alabama at Birmingham
Birmingham, Alabama 35294
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Kirklin Clinic
Birmingham, Alabama 35233
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Northwest Clinical Trials
Boise, Idaho 83704
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Drug Trials Brooklyn
Brooklyn, New York 12230
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Investigator's Research Group
Brownsburg, Indiana
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Community Health Care, Inc.
Canal Fulton, Ohio 44614
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Med Center
Carmichael, California 95608
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Radiant Research Incorporated
Chandler, Arizona 85224
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Coastal Cardiology
Charleston, South Carolina
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Sensenbrenner Primary Care
Charlotte, North Carolina 28277
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IHA Chelsea Family & Internal Medicine
Chelsea, Michigan 48118
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Sterling Research Group
Cincinnati, Ohio 45219
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The Lindner Center for Research and Education at The Christ Hospital
Cincinnati, Ohio 45219
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Metabolic And Atherosclerosis Research Center
Cincinnati, Ohio 45212
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Sentral Clinical Research Services - Admin Only
Cincinnati, Ohio 45236
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Sentral Clinical Research Services, LLC
Cincinnati, Ohio 45236
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Sterling Research Group
Cincinnati, Ohio 45219
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Morton Plant Mease Health Care, Inc. Cardiovascular Research
1200 Druid Road South
Clearwater, Florida 33756
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Clinicos, LLC
Colorado Springs, Colorado 80904
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Clinical Research Advantage, Inc. / Colorado Springs Health Partners, SW
Colorado Springs, Colorado 80906
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Columbia Medical Practice
Columbia, Maryland 21045
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West Broadway Clinic
Council Bluffs, Iowa 51501
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North Texas Healthcare System, Dallas VAMC
Dallas, Texas 75216
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Research Institute of Dallas
Dallas, Texas 75231
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Brandywine Clinical Research
Downingtown, Pennsylvania 19335
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Altoona Center for Clinical Research
Duncansville, Pennsylvania 16635
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Radiant Research, Inc.
Edina, Minnesota 55435
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Liberty Family Practice
Erie, Pennsylvania 16508
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Med Investigations
Fair Oaks, California 95628
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QUEST Research Institute
Farmington Hills, Michigan 48334
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Fleming Island Center for Clinical Research
Fleming Island, Florida 32003
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Invesclinic, LLC
Fort Lauderdale, Florida 33308
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University of North Texas Health Science Center at Fort Worth
Fort Worth, Texas 76107
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Florida Research Network
Gainesville, Florida 32605
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Advanced Research Associates
Glendale, Arizona 85308
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Pharmquest
Greensboro, North Carolina 27408
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Drug Trials America
Hartsdale, New York 10530
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The Research Center
Hialeah, Florida 33016
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Homestead Medical Research
Homestead, Florida 33030
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East-West Medical Research Institute
Honolulu, Hawaii 96814
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Northwest Houston Cardiology
Houston, Texas 77070
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Texas Center for Drug Development, P.A.
Houston, Texas
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Pioneer Research Solutions, Inc.
Houston, Texas 77098
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lnvestigational Drug Services (IDA)
Houston, Texas 77030
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California Heart Specialists
Huntington Beach, California 92648
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Alia Clinical research Inc
Huntington Park, California 90255
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Heart Center Research, Llc
Huntsville, Alabama 35801
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American Health Network
Indianapolis, Indiana 46254
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Midwest Institute for Clinical Research
Indianapolis, Indiana 46260
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Nature Coast Clinical Research
Inverness, Florida 34452
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University of Iowa College of Public Health - Preventive Intervention Center
Iowa City, Iowa 52242
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Westside Center for Clinical Research
Jacksonville, Florida 32205
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East Coast Institute for Research, LLC at Baker-Gilmour Cardiovascular Institute, PA
Jacksonville, Florida 32216
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East Coast Institute for Research, LLC at Jacksonville Cardiovascular Center
Jacksonville, Florida 32216
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St. Vincent's Cardiology
Jacksonville, Florida 32216
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East Coast Institute for Research, LLC at Northeast Florida Cardiology Clinic
3550 University Boulevard South
Jacksonville, Florida 32216
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Westside Family Medical Center
Kalamazoo, Michigan 49009
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University of Kansas Medical Center
3901 Rainbow Blvd
Kansas City, Kansas 66160
(913) 588-5000
University of Kansas Medical Center The University of Kansas Medical Center serves Kansas through excellence...
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KCUMB Center for Community and Clinical Research
Kansas City, Missouri 64106
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Cardiovascular Research of Knoxville
Knoxville, Tennessee 37917
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New Orleans Center for Clinical Research
Knoxville, Tennessee 37920
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Volunteer Research Group
Knoxville, Tennessee 37920
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Detweiler Family Medicine and Associates, PC
Lansdale, Pennsylvania 19446
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OM Medical
Las Vegas, Nevada 89119
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Clinical Research of South Nevada
Las Vegas, Nevada 89121
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Sjh Cardiology Associates
Liverpool, New York 13088
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Downtown L.A. Research Center, Inc.
Los Angeles, California 90017
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Richard S Cherlin
Los Gatos, California 95032
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Manassas Clinical Research Center
Manassas, Virginia 20110
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Clinical Research Institute of Southern Oregon, PC
Medford, Oregon 97504
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Suburban Research Associates
Media, Pennsylvania 19063
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Solaris Clinical Research
Meridian, Idaho 83646
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Arizona Center For Internal Medicine
Mesa, Arizona 85205
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Omega Clinical Research, Llc
Metairie, Louisiana 70006
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San Marcus Research Clinic
Miami, Florida 33015
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Clinical Research Of Miami, Inc.
Miami, Florida 33126
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Finlay Medical Research
Miami, Florida 33126
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Medical Research Center
286 Westward Drive
Miami, Florida 33144
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Kendall South Medical Center, Inc.
Miami, Florida 33175
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Crossroads Clinical Research, Inc.
Mooresville, North Carolina 28117
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Radiant Research, Inc.
Murray, Utah 84123
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Hill Country Medical Associates
New Braunfels, Texas 78130
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Rutgers Biomedical and Health Sciences - Robert Wood Johnson Medical School
New Brunswick, New Jersey 08901
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New Orleans Center for Clinical Research
New Orleans, Louisiana 70119
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Mid Hudson Medical Research
New Windsor, New York 12553
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