Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:8/2/2018
Start Date:October 29, 2013
End Date:July 10, 2017

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 3 Double-blind, Randomized, Placebo-controlled, Parallel-group Study To Assess The Efficacy, Long-term Safety And Tolerability Of Pf-04950615 In Subjects With Primary Hyperlipidemia Or Mixed Dyslipidemia At Risk Of Cardiovascular Events

This study is a multicenter, randomized study in subjects with high cholesterol receiving
highly effective statins to assess the efficacy, safety and tolerability of Bococizumab
(PF-04950615;RN316) to lower LDL-C.


Inclusion Criteria:

- Treated with a statin.

- Fasting LDL-C > 70 mg/dL and triglyceride <=400 mg/dL.

- High or very high risk of incurring a cardiovascular event.

Exclusion Criteria:

- Pregnant or breastfeeding females.

- Cardiovascular or cerebrovascular event of procedures during the past 30 days.

- Congestive heart failure NYHA class IV.

- Poorly controlled hypertension.
We found this trial at
156
sites
East-West Medical Research Institute
Honolulu, Hawaii 96814
4501
mi
from 43215
Honolulu, HI
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Avail Clinical Research
860 Peachwood Drive
DeLand, Florida 32720
(386) 740-0770
Site Overview Avail Clinical Research is a renowned and experienced clinical research site conducting Phase...
760
mi
from 43215
DeLand, FL
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Upstate Pharmaceutical Research
30 Pointe Circle
Greenville, South Carolina 29615
(864)255-3540
354
mi
from 43215
Greenville, SC
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AGA Clinical Trials
900 W 49th St # 430
Hialeah, Florida 33012
986
mi
from 43215
Hialeah, FL
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Baylor College of Medicine
1200 Moursund Street
Houston, Texas 77030
(713) 798-4951
Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
991
mi
from 43215
Houston, TX
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International Research Associates
8200 SW 117th Ave # 210
Miami, Florida 33183
997
mi
from 43215
Miami, FL
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Radiant Research, Inc.
Akron, Ohio 44311
109
mi
from 43215
Akron, OH
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Albany Medical College Division of Community Endocrinology
Albany, New York 12206
514
mi
from 43215
Albany, NY
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KRK Medical Research
Arlington, Texas 76012
928
mi
from 43215
Arlington, TX
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North Alabama Research Center
Athens, Alabama 35811
406
mi
from 43215
Athens, AL
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Ernest L. Hendrix, MD, PC
108 Sanders Street
Athens, Alabama 35611
417
mi
from 43215
Athens, AL
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Atlanta Diabetes Associates
Atlanta, Georgia 30309
432
mi
from 43215
Atlanta, GA
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ACRC - Cardiology
Atlantis, Florida 33462
939
mi
from 43215
Atlantis, FL
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Care Clinical Research Corporation
Banning, California 92220
1903
mi
from 43215
Banning, CA
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Southern Maine Health Care
Biddeford, Maine 04005
691
mi
from 43215
Biddeford, ME
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Alabama Internal Medicine, PC
Birmingham, Alabama 35235
492
mi
from 43215
Birmingham, AL
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Drug Shipment and Study Conducted at Address: University of Alabama at Birmingham
Birmingham, Alabama 35294
492
mi
from 43215
Birmingham, AL
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Kirklin Clinic
Birmingham, Alabama 35233
492
mi
from 43215
Birmingham, AL
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Northwest Clinical Trials
Boise, Idaho 83704
1720
mi
from 43215
Boise, ID
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Drug Trials Brooklyn
Brooklyn, New York 12230
280
mi
from 43215
Brooklyn, NY
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Investigator's Research Group
Brownsburg, Indiana
178
mi
from 43215
Brownsburg, IN
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Community Health Care, Inc.
Canal Fulton, Ohio 44614
98
mi
from 43215
Canal Fulton, OH
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Med Center
Carmichael, California 95608
2034
mi
from 43215
Carmichael, CA
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Radiant Research Incorporated
Chandler, Arizona 85224
1655
mi
from 43215
Chandler, AZ
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Coastal Cardiology
Charleston, South Carolina
525
mi
from 43215
Charleston, SC
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Sensenbrenner Primary Care
Charlotte, North Carolina 28277
348
mi
from 43215
Charlotte, NC
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IHA Chelsea Family & Internal Medicine
Chelsea, Michigan 48118
?
mi
from 43215
Chelsea, MI
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Sterling Research Group
Cincinnati, Ohio 45219
98
mi
from 43215
Cincinnati, OH
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The Lindner Center for Research and Education at The Christ Hospital
Cincinnati, Ohio 45219
98
mi
from 43215
Cincinnati, OH
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Metabolic And Atherosclerosis Research Center
Cincinnati, Ohio 45212
94
mi
from 43215
Cincinnati, OH
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Sentral Clinical Research Services - Admin Only
Cincinnati, Ohio 45236
94
mi
from 43215
Cincinnati, OH
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Sentral Clinical Research Services, LLC
Cincinnati, Ohio 45236
98
mi
from 43215
Cincinnati, OH
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Sterling Research Group
Cincinnati, Ohio 45219
98
mi
from 43215
Cincinnati, OH
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Morton Plant Mease Health Care, Inc. Cardiovascular Research
1200 Druid Road South
Clearwater, Florida 33756
829
mi
from 43215
Clearwater, FL
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Clinicos, LLC
Colorado Springs, Colorado 80904
1163
mi
from 43215
Colorado Springs, CO
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Clinical Research Advantage, Inc. / Colorado Springs Health Partners, SW
Colorado Springs, Colorado 80906
1163
mi
from 43215
Colorado Springs, CO
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Columbia Medical Practice
Columbia, Maryland 21045
331
mi
from 43215
Columbia, MD
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West Broadway Clinic
Council Bluffs, Iowa 51501
679
mi
from 43215
Council Bluffs, IA
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North Texas Healthcare System, Dallas VAMC
Dallas, Texas 75216
911
mi
from 43215
Dallas, TX
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Research Institute of Dallas
Dallas, Texas 75231
905
mi
from 43215
Dallas, TX
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Brandywine Clinical Research
Downingtown, Pennsylvania 19335
386
mi
from 43215
Downingtown, PA
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Altoona Center for Clinical Research
Duncansville, Pennsylvania 16635
244
mi
from 43215
Duncansville, PA
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Radiant Research, Inc.
Edina, Minnesota 55435
625
mi
from 43215
Edina, MN
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Liberty Family Practice
Erie, Pennsylvania 16508
211
mi
from 43215
Erie, PA
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Med Investigations
Fair Oaks, California 95628
2031
mi
from 43215
Fair Oaks, CA
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QUEST Research Institute
Farmington Hills, Michigan 48334
176
mi
from 43215
Farmington Hills, MI
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Fleming Island Center for Clinical Research
Fleming Island, Florida 32003
685
mi
from 43215
Fleming Island, FL
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Invesclinic, LLC
Fort Lauderdale, Florida 33308
966
mi
from 43215
Fort Lauderdale, FL
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University of North Texas Health Science Center at Fort Worth
Fort Worth, Texas 76107
940
mi
from 43215
Fort Worth, TX
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Florida Research Network
Gainesville, Florida 32605
713
mi
from 43215
Gainesville, FL
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Advanced Research Associates
Glendale, Arizona 85308
1662
mi
from 43215
Glendale, AZ
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Pharmquest
Greensboro, North Carolina 27408
318
mi
from 43215
Greensboro, NC
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Drug Trials America
Hartsdale, New York 10530
489
mi
from 43215
Hartsdale, NY
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The Research Center
Hialeah, Florida 33016
984
mi
from 43215
Hialeah, FL
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Homestead Medical Research
Homestead, Florida 33030
1012
mi
from 43215
Homestead, FL
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Northwest Houston Cardiology
Houston, Texas 77070
995
mi
from 43215
Houston, TX
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Texas Center for Drug Development, P.A.
Houston, Texas
991
mi
from 43215
Houston, TX
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Pioneer Research Solutions, Inc.
Houston, Texas 77098
994
mi
from 43215
Houston, TX
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lnvestigational Drug Services (IDA)
Houston, Texas 77030
995
mi
from 43215
Houston, TX
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California Heart Specialists
Huntington Beach, California 92648
1969
mi
from 43215
Huntington Beach, CA
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Alia Clinical research Inc
Huntington Park, California 90255
1972
mi
from 43215
Huntington Park, CA
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Heart Center Research, Llc
Huntsville, Alabama 35801
410
mi
from 43215
Huntsville, AL
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American Health Network
Indianapolis, Indiana 46254
171
mi
from 43215
Indianapolis, IN
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Midwest Institute for Clinical Research
Indianapolis, Indiana 46260
167
mi
from 43215
Indianapolis, IN
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Nature Coast Clinical Research
Inverness, Florida 34452
772
mi
from 43215
Inverness, FL
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University of Iowa College of Public Health - Preventive Intervention Center
Iowa City, Iowa 52242
460
mi
from 43215
Iowa City, IA
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Westside Center for Clinical Research
Jacksonville, Florida 32205
670
mi
from 43215
Jacksonville, FL
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East Coast Institute for Research, LLC at Baker-Gilmour Cardiovascular Institute, PA
Jacksonville, Florida 32216
669
mi
from 43215
Jacksonville, FL
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East Coast Institute for Research, LLC at Jacksonville Cardiovascular Center
Jacksonville, Florida 32216
669
mi
from 43215
Jacksonville, FL
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East Coast Institute for Research, LLC at Northeast Florida Endocrine & Diabetes Associates
Jacksonville, Florida 32204
670
mi
from 43215
Jacksonville, FL
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St. Vincent's Cardiology
Jacksonville, Florida 32216
669
mi
from 43215
Jacksonville, FL
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East Coast Institute for Research, LLC at Northeast Florida Cardiology Clinic
3550 University Boulevard South
Jacksonville, Florida 32216
673
mi
from 43215
Jacksonville, FL
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Westside Family Medical Center
Kalamazoo, Michigan 49009
210
mi
from 43215
Kalamazoo, MI
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University of Kansas Medical Center
3901 Rainbow Blvd
Kansas City, Kansas 66160
(913) 588-5000
University of Kansas Medical Center The University of Kansas Medical Center serves Kansas through excellence...
627
mi
from 43215
Kansas City, KS
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KCUMB Center for Community and Clinical Research
Kansas City, Missouri 64106
618
mi
from 43215
Kansas City, MO
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Cardiovascular Research of Knoxville
Knoxville, Tennessee 37917
280
mi
from 43215
Knoxville, TN
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New Orleans Center for Clinical Research
Knoxville, Tennessee 37920
280
mi
from 43215
Knoxville, TN
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Volunteer Research Group
Knoxville, Tennessee 37920
283
mi
from 43215
Knoxville, TN
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Detweiler Family Medicine and Associates, PC
Lansdale, Pennsylvania 19446
409
mi
from 43215
Lansdale, PA
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OM Medical
Las Vegas, Nevada 89119
1759
mi
from 43215
Las Vegas, NV
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Clinical Research of South Nevada
Las Vegas, Nevada 89121
1755
mi
from 43215
Las Vegas, NV
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Sjh Cardiology Associates
Liverpool, New York 13088
414
mi
from 43215
Liverpool, NY
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Downtown L.A. Research Center, Inc.
Los Angeles, California 90017
1973
mi
from 43215
Los Angeles, CA
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Richard S Cherlin
Los Gatos, California 95032
2093
mi
from 43215
Los Gatos, CA
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Manassas Clinical Research Center
Manassas, Virginia 20110
307
mi
from 43215
Manassas, VA
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Clinical Research Institute of Southern Oregon, PC
Medford, Oregon 97504
2058
mi
from 43215
Medford, OR
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Suburban Research Associates
Media, Pennsylvania 19063
403
mi
from 43215
Media, PA
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Solaris Clinical Research
Meridian, Idaho 83646
1727
mi
from 43215
Meridian, ID
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Arizona Center For Internal Medicine
Mesa, Arizona 85205
1644
mi
from 43215
Mesa, AZ
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Omega Clinical Research, Llc
Metairie, Louisiana 70006
797
mi
from 43215
Metairie, LA
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San Marcus Research Clinic
Miami, Florida 33015
981
mi
from 43215
Miami, FL
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Clinical Research Of Miami, Inc.
Miami, Florida 33126
996
mi
from 43215
Miami, FL
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Finlay Medical Research
Miami, Florida 33126
992
mi
from 43215
Miami, FL
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Medical Research Center
286 Westward Drive
Miami, Florida 33144
989
mi
from 43215
Miami, FL
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Kendall South Medical Center, Inc.
Miami, Florida 33175
994
mi
from 43215
Miami, FL
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Crossroads Clinical Research, Inc.
Mooresville, North Carolina 28117
325
mi
from 43215
Mooresville, NC
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Radiant Research, Inc.
Murray, Utah 84123
1516
mi
from 43215
Murray, UT
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Hill Country Medical Associates
New Braunfels, Texas 78130
1108
mi
from 43215
New Braunfels, TX
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Rutgers Biomedical and Health Sciences - Robert Wood Johnson Medical School
New Brunswick, New Jersey 08901
453
mi
from 43215
New Brunswick, NJ
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New Orleans Center for Clinical Research
New Orleans, Louisiana 70119
796
mi
from 43215
New Orleans, LA
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Mid Hudson Medical Research
New Windsor, New York 12553
480
mi
from 43215
New Windsor, NY
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