Renal Denervation in Patients With Uncontrolled Hypertension - SYMPLICITY HTN-4

After the 6 month follow-up required testing has been completed, control group subjects
would be unblinded to their randomization group and would have an option, at the discretion
of the Investigator and with written concurrence of the medical monitor, to be treated with
renal denervation procedure. However, after enrollment closure, subjects previously
randomized were no longer allowed to cross-over.

Inclusion Criteria:

- Individual is on maximally tolerated stable medication regimen including 3 or more
anti-hypertensive medications of different classes, one of which must be a thiazide
or thiazide-like diuretic

- Individual has office SBP greater than or equal to 140mmHg and less than 160mmHg

- Individual has ABPM average SBP greater than or equal to 135 mmHg

Exclusion Criteria:

- Individual lacks appropriate renal artery anatomy

- Individual has eGFR of less than 30

- Individual has Type I diabetes mellitus

- Individual has had one or more episodes of orthostatic hypotension

- Individual requires chronic oxygen other than nocturnal respiratory support for sleep
apnea

- Individual has primary pulmonary hypertension

- Individual has other concomitant conditions that may adversely affect the patient or
the study outcomes

- Individual is pregnant, nursing or planning to be pregnant

- Individual has had a previous organ transplant