Efficacy and Safety of Atacicept in Systemic Lupus Erythematosus



Status:Completed
Conditions:Lupus
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:18 - Any
Updated:1/3/2018
Start Date:December 2013
End Date:September 2016

Use our guide to learn which trials are right for you!

A Phase IIb, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Multidose, 24-Week Study to Evaluate the Efficacy and Safety of Atacicept in Subjects With Systemic Lupus Erythematosus (SLE)

This is a multi-center, double-blind, randomized, Phase 2b trial to evaluate the efficacy of
atacicept in subjects with systemic lupus erythematosus (SLE).


Inclusion Criteria:

- Eligible male and female subjects, aged 18 years or older

- Must have at least moderately active SLE, as defined as SLE Disease Activity
Index-2000 (SLEDAI-2K) score greater than or equal to [>=] 6 at screening visit

- At least 4 of the 11 American college of rheumatology (ACR) classification criteria
for SLE (diagnosed >= 6 months prior to the screening visit)

- Be seropositive for anti-nuclear antibodies (ANA) and/or anti-double-stranded
deoxyribonucleic acid (anti-dsDNA) antibodies

- Other protocol defined inclusion criteria could apply

Exclusion Criteria:

- Subjects have demyelinating disorder

- Severe central nervous system SLE

- Use of cyclophosphamide within 3 months of the screening visit

- Urine protein:creatinine ratio (UPCr) >= 2 milligram per milligram (mg/mg) per day

- Other protocol defined exclusion criteria could apply
We found this trial at
31
sites
2017 Canyon Road, Suite 41
Birmingham, Alabama 35216
(205) 757-8208
Site Overview Achieve has two clinical research sites in Birmingham, AL. Our Birmingham sites are conveniently located...
2084
mi
from 98109
Birmingham, AL
Click here to add this to my saved trials
1601 Northwest 12th Avenue
Miami, Florida 33136
(305) 243-6545
University of Miami Miller School of Medicine The University of Miami Leonard M. Miller School...
2730
mi
from 98109
Miami, FL
Click here to add this to my saved trials
980
mi
from 98109
Anaheim, CA
Click here to add this to my saved trials
Anniston, Alabama 36207
2121
mi
from 98109
Anniston, AL
Click here to add this to my saved trials
Birmingham, Alabama 35294
2072
mi
from 98109
Birmingham, AL
Click here to add this to my saved trials
Charleston, South Carolina 29425
2422
mi
from 98109
Charleston, SC
Click here to add this to my saved trials
Charlotte, North Carolina 00000
2281
mi
from 98109
Charlotte, NC
Click here to add this to my saved trials
Ciudad Autonoma Buenos aires,
6918
mi
from 98109
Ciudad Autonoma Buenos aires,
Click here to add this to my saved trials
Cleveland, Ohio 44109
2021
mi
from 98109
Cleveland, OH
Click here to add this to my saved trials
2007
mi
from 98109
Columbus, OH
Click here to add this to my saved trials
Danville, Virginia 24541
2295
mi
from 98109
Danville, VA
Click here to add this to my saved trials
Dayton, Ohio 45417
1957
mi
from 98109
Dayton, OH
Click here to add this to my saved trials
2509
mi
from 98109
Dunedin, FL
Click here to add this to my saved trials
Fort Lauderdale, Florida 33334
2717
mi
from 98109
Fort Lauderdale, FL
Click here to add this to my saved trials
Galveston, Texas 77555
1937
mi
from 98109
Galveston, TX
Click here to add this to my saved trials
Grand Blanc, Michigan 48439
1889
mi
from 98109
Grand Blanc, MI
Click here to add this to my saved trials
Indianapolis, Indiana 46260
1862
mi
from 98109
Indianapolis, IN
Click here to add this to my saved trials
Los Angeles, California 90048
959
mi
from 98109
Los Angeles, CA
Click here to add this to my saved trials
2413
mi
from 98109
Manhasset, NY
Click here to add this to my saved trials
535 E 70th St
New York, New York 10021
(212) 606-1000
Hospital for Special Surgery Founded in 1863, Hospital for Special Surgery is the nation
2402
mi
from 98109
New York, NY
Click here to add this to my saved trials
Newark, New Jersey 07103
2392
mi
from 98109
Newark, NJ
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73103
1522
mi
from 98109
Oklahoma City, OK
Click here to add this to my saved trials
3555 NW 58th St # 800
Oklahoma City, Oklahoma 73112
(405) 447-8839
Lynn Health Science Institute Our mission is to provide clinical trials research and health services...
1523
mi
from 98109
Oklahoma City, OK
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73104
1523
mi
from 98109
Oklahoma City, OK
Click here to add this to my saved trials
Rochester, Minnesota 55905
1450
mi
from 98109
Rochester, MN
Click here to add this to my saved trials
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
1718
mi
from 98109
Saint Louis, MO
Click here to add this to my saved trials
San Leandro, California 94578
686
mi
from 98109
San Leandro, CA
Click here to add this to my saved trials
5115 North Armenia Avenue
Tampa, Florida 33603
2523
mi
from 98109
Tampa, FL
Click here to add this to my saved trials
Tupelo, Mississippi 38801
1962
mi
from 98109
Tupelo, MS
Click here to add this to my saved trials
1728
mi
from 98109
Waco, TX
Click here to add this to my saved trials
Wyomissing, Pennsylvania 19610
2323
mi
from 98109
Wyomissing, PA
Click here to add this to my saved trials