Seizure Prophylaxis in Aneurysm Repair
| Status: | Terminated |
|---|---|
| Conditions: | Cardiology, Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | July 2013 |
| End Date: | February 2016 |
Seizures are a potential complication of surgical repair of intracranial aneurysms. In order
to prevent seizures, many surgeons administer prophylactic anti-epileptic medication during
the intra-operative and post-operative period, however, such practice is not supported by
clinical data. Retrospective review found the incidence of postoperative seizures was higher
in those who received anti-epileptics versus those who did not. The goal is to examine the
utility of levetiracetam (Keppra) for seizure prophylaxis in patients undergoing surgical
repair of unruptured intracranial aneurysms.
to prevent seizures, many surgeons administer prophylactic anti-epileptic medication during
the intra-operative and post-operative period, however, such practice is not supported by
clinical data. Retrospective review found the incidence of postoperative seizures was higher
in those who received anti-epileptics versus those who did not. The goal is to examine the
utility of levetiracetam (Keppra) for seizure prophylaxis in patients undergoing surgical
repair of unruptured intracranial aneurysms.
Inclusion Criteria:
1. Adult (≥18 years)
2. Presence of intracranial aneurysm (without rupture)
3. Treating surgeon has recommended surgical repair of the aneurysm.
Exclusion Criteria:
1. History of seizures within last 10 years
2. History of epilepsy
3. History of prior stroke
4. Currently prescribed medication with anti-epileptic activity (keppra,dilantin,
tegretol, lamictal, topamax, etc.)
5. Brain tumor
6. Pregnant or nursing woman
7. Known levetiracetam allergy
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