Efficacy and Safety of Semaglutide Once-weekly Versus Exenatide ER 2.0 mg Once-weekly as add-on to 1-2 Oral Antidiabetic Drugs (OADs) in Subjects With Type 2 Diabetes



Status:Completed
Conditions:Diabetes, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - Any
Updated:3/28/2019
Start Date:December 2, 2013
End Date:July 13, 2015

Use our guide to learn which trials are right for you!

Efficacy and Safety of Semaglutide Once-weekly Versus Exenatide ER 2.0 mg Once-weekly as add-on to 1-2 Oral Antidiabetic Drugs (OADs) in Subjects With Type 2 Diabetes (SUSTAIN™ 3 - vs. QW GLP-1)

This trial is conducted in Europe and North and South America. The aim of the trial is to
investigate the efficacy and safety of semaglutide once-weekly versus exenatide ER (extended
release) 2.0 mg once-weekly as add-on to 1-2 oral antidiabetic drugs (OADs) in subjects with
type 2 diabetes.


Inclusion Criteria: - Subjects diagnosed with type 2 diabetes and on stable diabetes
treatment with 1-2 OADs (Metformin equal to or above 1500 mg or maximum tolerated dose
and/or thiazolidinedione (TZD) and sulfonylureas (SUs) equal to or above half of maximum
dose allowed according to national label) for at least 90 days prior to screening. Stable
is defined as unchanged medication and unchanged dose - HbA1c 7.0 - 10.5 % (53 - 91
mmol/mol) (both inclusive) Exclusion Criteria: - Females of childbearing potential who are
pregnant, breast-feeding or intend to become pregnant or are not using an adequate
contraceptive method throughout the trial including the 5 week follow-up period (adequate
contraceptive measures as required by local law or practice) - Any chronic disorder or
severe disease which, in the opinion of the investigator, might jeopardise subject's safety
or compliance with the protocol - Treatment with glucose lowering agent(s) other than
stated in the inclusion criteria in a period of 90 days before screening. An exception is
short-term treatment (7 days or less in total) with insulin in connection with
inter-current illness - History of chronic or idiopathic acute pancreatitis - Screening
calcitonin value equal to or above 50 ng/L (pg/mL) - Personal or family history of
medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2) -
Impaired renal function defined as estimated glomerular filtration rate (eGFR) below 60
ml/min/1.73 m^2 per modification of diet in renal disease (MDRD) formula (4 variable
version) - Acute coronary or cerebrovascular event within 90 days before randomisation -
Heart failure, New York Heart Association (NYHA) class IV
We found this trial at
65
sites
Madisonville, Kentucky 42431
302
mi
from 43215
Madisonville, KY
Click here to add this to my saved trials
110
mi
from 43215
Akron, OH
Click here to add this to my saved trials
Albuquerque, New Mexico 87102
1333
mi
from 43215
Albuquerque, NM
Click here to add this to my saved trials
Alexandria, Virginia 22304
325
mi
from 43215
Alexandria, VA
Click here to add this to my saved trials
Anniston, Alabama 36207
462
mi
from 43215
Anniston, AL
Click here to add this to my saved trials
Austin, Texas 78731
1065
mi
from 43215
Austin, TX
Click here to add this to my saved trials
Birmingham, Alabama 35215
481
mi
from 43215
Birmingham, AL
Click here to add this to my saved trials
Bradenton, Florida 34201
868
mi
from 43215
Bradenton, FL
Click here to add this to my saved trials
Brandon, Florida 33511
832
mi
from 43215
Brandon, FL
Click here to add this to my saved trials
?
mi
from 43215
Buenos Aires,
Click here to add this to my saved trials
Burbank, California 91505
1974
mi
from 43215
Burbank, CA
Click here to add this to my saved trials
Carrollton, Texas 75007
906
mi
from 43215
Carrollton, TX
Click here to add this to my saved trials
Charleston, South Carolina 29407
522
mi
from 43215
Charleston, SC
Click here to add this to my saved trials
Chattanooga, Tennessee 37404
362
mi
from 43215
Chattanooga, TN
Click here to add this to my saved trials
Chicago, Illinois 60612
274
mi
from 43215
Chicago, IL
Click here to add this to my saved trials
Cincinnati, Ohio 45229
95
mi
from 43215
Cincinnati, OH
Click here to add this to my saved trials
Cleveland, Ohio 44106
126
mi
from 43215
Cleveland, OH
Click here to add this to my saved trials
Colorado Springs, Colorado 80910
1161
mi
from 43215
Colorado Springs, CO
Click here to add this to my saved trials
Coral Gables, Florida 33134
996
mi
from 43215
Coral Gables, FL
Click here to add this to my saved trials
Corvallis, Oregon 97330
2060
mi
from 43215
Corvallis, OR
Click here to add this to my saved trials
Dallas, Texas 75231
905
mi
from 43215
Dallas, TX
Click here to add this to my saved trials
Delaware, Ohio 43015
23
mi
from 43215
Delaware, OH
Click here to add this to my saved trials
Fort Worth, Texas 76104
937
mi
from 43215
Fort Worth, TX
Click here to add this to my saved trials
Franklin, Indiana 46131
114
mi
from 43215
Franklin, IN
Click here to add this to my saved trials
Glendale, Arizona 85306
1662
mi
from 43215
Glendale, AZ
Click here to add this to my saved trials
Greenfield, Indiana 46140
146
mi
from 43215
Greenfield, IN
Click here to add this to my saved trials
Greensboro, North Carolina 27408
321
mi
from 43215
Greensboro, NC
Click here to add this to my saved trials
Hawaiian Gardens, California 90716
1969
mi
from 43215
Hawaiian Gardens, CA
Click here to add this to my saved trials
Hialeah, Florida 33012
987
mi
from 43215
Hialeah, FL
Click here to add this to my saved trials
Hickory, North Carolina 28602
306
mi
from 43215
Hickory, NC
Click here to add this to my saved trials
Houston, Texas 77030
995
mi
from 43215
Houston, TX
Click here to add this to my saved trials
Hyattsville, Maryland 20782
331
mi
from 43215
Hyattsville, MD
Click here to add this to my saved trials
Irving, Texas 75061
914
mi
from 43215
Irving, TX
Click here to add this to my saved trials
Jacksonville, Florida 32207
672
mi
from 43215
Jacksonville, FL
Click here to add this to my saved trials
Kalamazoo, Michigan 49009
211
mi
from 43215
Kalamazoo, MI
Click here to add this to my saved trials
1008
mi
from 43215
Katy, TX
Click here to add this to my saved trials
Lansdale, Pennsylvania 19446
409
mi
from 43215
Lansdale, PA
Click here to add this to my saved trials
Las Vegas, Nevada 89128
1762
mi
from 43215
Las Vegas, NV
Click here to add this to my saved trials
Lomita, California 90717
1982
mi
from 43215
Lomita, CA
Click here to add this to my saved trials
Los Angeles, California 90027
1973
mi
from 43215
Los Angeles, CA
Click here to add this to my saved trials
Louisville, Kentucky 40213
189
mi
from 43215
Louisville, KY
Click here to add this to my saved trials
Mesa, Arizona 85206
1650
mi
from 43215
Mesa, AZ
Click here to add this to my saved trials
Miami, Florida 33136
992
mi
from 43215
Miami, FL
Click here to add this to my saved trials
Miami Lakes, Florida 33016
983
mi
from 43215
Miami Lakes, FL
Click here to add this to my saved trials
Mine Hill, New Jersey 07803
447
mi
from 43215
Mine Hill, NJ
Click here to add this to my saved trials
Mount Pleasant, South Carolina 29464
525
mi
from 43215
Mount Pleasant, SC
Click here to add this to my saved trials
Muncie, Indiana 47304
125
mi
from 43215
Muncie, IN
Click here to add this to my saved trials
Murrells Inlet, South Carolina 29576
494
mi
from 43215
Murrells Inlet, SC
Click here to add this to my saved trials
Norristown, Pennsylvania 19401
406
mi
from 43215
Norristown, PA
Click here to add this to my saved trials
North Massapequa, New York 11758
505
mi
from 43215
North Massapequa, NY
Click here to add this to my saved trials
Northridge, California 91325
1981
mi
from 43215
Northridge, CA
Click here to add this to my saved trials
Pell City, Alabama 35128
476
mi
from 43215
Pell City, AL
Click here to add this to my saved trials
Phoenix, Arizona 85053
1662
mi
from 43215
Phoenix, AZ
Click here to add this to my saved trials
Plantation, Florida 33324
970
mi
from 43215
Plantation, FL
Click here to add this to my saved trials
Portland, Oregon 97239
2026
mi
from 43215
Portland, OR
Click here to add this to my saved trials
Saint Louis, Missouri 63110
394
mi
from 43215
Saint Louis, MO
Click here to add this to my saved trials
San Antonio, Texas 78224
1138
mi
from 43215
San Antonio, TX
Click here to add this to my saved trials
San Diego, California 92111
1951
mi
from 43215
San Diego, CA
Click here to add this to my saved trials
Savannah, Georgia 31406
555
mi
from 43215
Savannah, GA
Click here to add this to my saved trials
Spartanburg, South Carolina 29303
351
mi
from 43215
Spartanburg, SC
Click here to add this to my saved trials
Sugar Land, Texas 77479
1009
mi
from 43215
Sugar Land, TX
Click here to add this to my saved trials
Syracuse, New York 13210
414
mi
from 43215
Syracuse, NY
Click here to add this to my saved trials
Tustin, California 92780
1957
mi
from 43215
Tustin, CA
Click here to add this to my saved trials
West Seneca, New York 14224
295
mi
from 43215
West Seneca, NY
Click here to add this to my saved trials
Whiteville, North Carolina 28472
455
mi
from 43215
Whiteville, NC
Click here to add this to my saved trials