A Bioavailability and Pharmacokinetic Study of GDC-0032 in Healthy Volunteers

Inclusion Criteria:

- Body Mass Index (BMI) 18 to 32 kg/m2, inclusive;

- Healthy, as judged by physician from medical history, 12-lead ECG, vital signs, and
clinical laboratory evaluations;

- Agree to use effective contraceptive methods as defined by protocol;

- Negative hepatitis panel and HIV screen;

- Sufficient bowel movements (minimum of 1 per day).

Exclusion Criteria:

- History or clinical manifestation of: any major medical disorders; any
food/drug/substance allergies;

- History of stomach or intestinal surgery or resection except for appendectomy and/or
hernia repair;

- History of alcoholism or drug addiction within 1 year prior to drug administration;

- Tobacco or nicotine use within 6 months prior to study start;

- Chronic use of gastric acid inhibitors within 6 months of study start or use of
gastric acid inhibitors and/or antacids within 1 month prior to drug administration;

- Evidence of malabsorption syndrome or other condition interfering with
gastrointestinal absorption;

- Inability or unwillingness to swallow capsules;

- Participation in a drug study in which a drug was administered within 30 days prior
to study start;

- Participation in more than one radiolabeled drug study within 12 months preceding
drug administration. The previous radiolabeled study drug must have been received
more than 6 months prior to this study, and the total exposure from this study and
the previous study is less than 5000 mrem whole body annual exposure;

- Exposure to significant radiation within 12 months prior to study start.