Fetal Thymus Involution as a Predictor of Adverse Neonatal Outcomes
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies, Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 4/21/2016 |
| Start Date: | March 2013 |
| End Date: | April 2014 |
Fetal Thymus Involution as a Predictor of Adverse Neonatal Outcome in Women at High Risk for Preterm Delivery
The thymus gland is a specialized organ in the chest that plays a central role in the
adaptive immune system throughout development until puberty. In response to stress, the
fetal thymus gland may shrink, or involute. The investigators propose a prospective cohort
study that will enroll pregnant women admitted to labor and delivery for the management of
preterm labor and/or preterm premature rupture of membranes from 28-36 weeks gestation.
Based on sonographic thymus measurements, the investigators will develop a clinical
prediction tool to identify babies who are at increased risk for adverse neonatal outcomes.
A reliable non-invasive predictor of adverse neonatal outcome using thymic ultrasound
measurements has the potential to affect clinical management, improve outcomes for premature
babies, and direct further research efforts.
adaptive immune system throughout development until puberty. In response to stress, the
fetal thymus gland may shrink, or involute. The investigators propose a prospective cohort
study that will enroll pregnant women admitted to labor and delivery for the management of
preterm labor and/or preterm premature rupture of membranes from 28-36 weeks gestation.
Based on sonographic thymus measurements, the investigators will develop a clinical
prediction tool to identify babies who are at increased risk for adverse neonatal outcomes.
A reliable non-invasive predictor of adverse neonatal outcome using thymic ultrasound
measurements has the potential to affect clinical management, improve outcomes for premature
babies, and direct further research efforts.
Inclusion Criteria:
- Singleton pregnancy between 28-36 weeks gestation
- Active spontaneous preterm labor symptoms (contractions, cervical dilatation and/or
PPROM)
Exclusion Criteria:
- Non-singleton pregnancies
- Gestational hypertension/preeclampsia
- Major fetal anomalies
- Known fetal aneuploidy
- Intrauterine Fetal Demise
We found this trial at
1
site
3400 Spruce St
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
(215) 662-4000
Hospital of the University of Pennsylvania The Hospital of the University of Pennsylvania (HUP) is...
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