A Pilot Study Testing 1064nm Q-switch Laser Versus Glycolic Acid Peels for the Treatment of Melasma

Participants in this study will be patients at the dermatology clinic who are clinically
diagnosed with at least a 2X2 cm patch of melasma on each side of their face (forehead or
cheek). Starting at 2 weeks before treatment (week 2), both sides will be pretreated and
primed with 4% hydroquinone with, if necessary, 2.5% hydrocortisone cream BID. On the
treatment day (2-weeks) and 6-weeks one half of the subject's face will receive glycolic
acid peels and the other half of the face will receive 1064nm Q-switch laser. This study is
a pilot study designed to determine feasibility of these procedures.

Inclusion Criteria:

1. Subjects aged 18 years or older

2. Subjects with at least a 2 x 2 cm patch of melasma on each side of the face (forehead
or cheek)

3. Subjects in general good health

4. Subjects must be willing and able to understand and provide informed consent for the
use of their tissue and communicate with the investigator

5. Subjects must be willing to not apply other treatment options for melasma during the
course of the study

Exclusion Criteria:

1. Subjects under 18 years of age

2. Subjects who are pregnant and/or lactating

3. Subjects who are unable to understand the protocol or to give informed consent

4. Subjects diagnosed with mental illness

5. Subjects who have concurrent active uncontrolled disease to facial area (i.e
uncontrolled acne)

6. Subjects who have had a chemical peel in the past 3 months

7. Subjects who have used a prescribed retinoid in the past 3 months

8. Subjects with a bleeding disorder

9. Subjects with a history of abnormal wound healing

10. Subjects with a history of abnormal scarring

11. Subjects who report being allergic to glycolic acid