Iron Sucrose in Adolescents With Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS)

Inclusion criteria

- aged 12-21 years

- chronic (>3 months)symptoms of orthostatic intolerance (including but not limited to
lightheadedness, syncope, headache, fatigue, weakness, sweating, nausea and
palpitations)

- symptomatic orthostatic heart rate increase of greater than or equal to 40 beats per
minute during a 10 minute 70 degree head up tilt study

- presence of non-anemic iron deficiency, defined as serum ferritin level less than or
equal to 20 ug/L with normal hemoglobin

Exclusion criteria

- orthostatic hypotension within 3 minutes of 70 degree head up tilt

- pregnant or lactating females

- presence of other organ failure or systemic illness that can affect autonomic function

- concurrent medication therapy with anticholinergic, alpha-adrenergic antagonists,
beta-adrenergic antagonists unless medication is held for five half-lives prior to
study

- laboratory evidence of anemia or iron overload

- personal history of hematochromatosis or first degree relative with hematochromatosis

- known sensitivity to Venofer (TM) or other intravenous iron preparations