Developmental Origins of Attention Deficit Hyperactivity Disorder
| Status: | Completed |
|---|---|
| Conditions: | Anxiety, Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 4/2/2016 |
| Start Date: | August 2012 |
| End Date: | August 2014 |
| Contact: | Joel Nigg, PhD |
| Email: | niggj@ohsu.edu |
| Phone: | 503 418-8498 |
This is a study evaluating the relationship between prenatal nutrition and neural
development in infants born to mothers with Attention Deficit Hyperactivity Disorder (ADHD).
We are hypothesizing that women randomized to a whole food, nutrient-dense diet during their
3rd trimester of pregnancy will have infants with more advanced neural development as
compared to infants born to mothers receiving standard-of-care treatment.
development in infants born to mothers with Attention Deficit Hyperactivity Disorder (ADHD).
We are hypothesizing that women randomized to a whole food, nutrient-dense diet during their
3rd trimester of pregnancy will have infants with more advanced neural development as
compared to infants born to mothers receiving standard-of-care treatment.
Pregnant women with ADHD will be recruited from the patient population at Oregon Health &
Science University (OHSU). They will be recruited during their 1st or 2nd trimester. After
consent, baseline measures will be collected including height, weight, body composition
measurements using calipers, 24-hour dietary recalls, and blood and urine samples. Women
will also complete questionnaires regarding ADHD symptoms, stress, depression, and
lifestyle. Women will be given a one-week food diary to fill out at home, which will be
mailed in upon completion. Upon receipt of the food diary, women will be randomized into
either a nutrition intervention group or a standard-of-care group. Women who are randomized
to the intervention group will receive individual nutritional counseling every 2 weeks
during their 3rd trimester of pregnancy. Before delivery, the baseline measures described
above will again be collected. At delivery, placenta and cord blood samples will be taken.
After birth, the infant will undergo an MRI between 2 and 5 weeks of age. The scan is
completed while the baby sleeps, and special ear protection is worn to limit sleep
disruption from the noise of the MRI. When the infant is 3 months old, mothers will complete
questionnaires about infant feeding, sleep and behavior.
Science University (OHSU). They will be recruited during their 1st or 2nd trimester. After
consent, baseline measures will be collected including height, weight, body composition
measurements using calipers, 24-hour dietary recalls, and blood and urine samples. Women
will also complete questionnaires regarding ADHD symptoms, stress, depression, and
lifestyle. Women will be given a one-week food diary to fill out at home, which will be
mailed in upon completion. Upon receipt of the food diary, women will be randomized into
either a nutrition intervention group or a standard-of-care group. Women who are randomized
to the intervention group will receive individual nutritional counseling every 2 weeks
during their 3rd trimester of pregnancy. Before delivery, the baseline measures described
above will again be collected. At delivery, placenta and cord blood samples will be taken.
After birth, the infant will undergo an MRI between 2 and 5 weeks of age. The scan is
completed while the baby sleeps, and special ear protection is worn to limit sleep
disruption from the noise of the MRI. When the infant is 3 months old, mothers will complete
questionnaires about infant feeding, sleep and behavior.
Inclusion Criteria:
- Women in general good health
- 18 years of age or older
- Confirmed pregnancy and currently between 8 and 24 weeks pregnant
- With symptoms of inattention or impulsivity
Exclusion Criteria:
- Obstetrician confirmed high-risk pregnancy
- Current drug/alcohol addiction
- Current smoker
- Unwilling/unable to discontinue psychiatric medication during pregnancy
- Comorbid schizophrenia, bipolar, or major depressive disorder
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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