Anesthesia Depth And Postoperative Delirium Trial 2
| Status: | Recruiting |
|---|---|
| Conditions: | Cognitive Studies, Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 64 - Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2015 |
| End Date: | December 2018 |
| Contact: | Jacqueline Leung, MD, MPH |
| Email: | leungj@anesthesia.ucsf.edu |
| Phone: | 415-476-0711 |
THE EFFECTS OF LIGHT vs DEEP ANESTHESIA ON POSTOPERATIVE COGNITIVE OUTCOMES
There is recent, but limited evidence to suggest that anesthetic depth is associated with
poor postoperative cognitive outcomes. Specifically, several studies suggest that deeper
level of anesthesia is associated with increased incidence of postoperative delirium and
longer-term cognitive decline. In fact, some suggest that older patients undergoing surgery
should routinely be monitored with an anesthetic depth monitor to allow the titration of
anesthetics or sedation medications to lighter levels to promote better postoperative
cognitive outcomes. However, such a practice has never been validated or proven to be
feasible or safe. Accordingly, the investigators plan an exploratory study to determine the
feasibility and safety of randomizing patients undergoing major surgery to receive deep vs.
light anesthetic levels during surgery.
poor postoperative cognitive outcomes. Specifically, several studies suggest that deeper
level of anesthesia is associated with increased incidence of postoperative delirium and
longer-term cognitive decline. In fact, some suggest that older patients undergoing surgery
should routinely be monitored with an anesthetic depth monitor to allow the titration of
anesthetics or sedation medications to lighter levels to promote better postoperative
cognitive outcomes. However, such a practice has never been validated or proven to be
feasible or safe. Accordingly, the investigators plan an exploratory study to determine the
feasibility and safety of randomizing patients undergoing major surgery to receive deep vs.
light anesthetic levels during surgery.
In this exploratory grant, the investigators aim to determine whether two different
anesthetic depths as measured by an anesthetic depth monitor can be practiced uniformly by a
number of anesthesia providers and with safety across a large group of older surgical
patients. The investigators will use a randomized control trial design to randomize 232
patients in receiving "light" vs "deep" anesthesia as measured by an anesthetic depth
monitor. Postoperative outcomes will include delirium and cognitive measurements.
anesthetic depths as measured by an anesthetic depth monitor can be practiced uniformly by a
number of anesthesia providers and with safety across a large group of older surgical
patients. The investigators will use a randomized control trial design to randomize 232
patients in receiving "light" vs "deep" anesthesia as measured by an anesthetic depth
monitor. Postoperative outcomes will include delirium and cognitive measurements.
Inclusion Criteria:
- 65 years and older of age undergoing non-cardiac surgery
Exclusion Criteria:
- patients' who are not fluent in English or cannot provide informed consent
We found this trial at
1
site
505 Parnassus Ave
San Francisco, California 94143
San Francisco, California 94143
(415) 476-1000
Principal Investigator: Jacqueline Leung, MD, MPH
University of California, San Francisco Medical Center UCSF Medical Center is recognized throughout the world...
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