Effect of Chemotherapy on Pain Sensitivity and Patient-reported Symptoms



Status:Completed
Conditions:Breast Cancer, Cancer, Chronic Pain, Chronic Pain
Therapuetic Areas:Musculoskeletal, Oncology
Healthy:No
Age Range:18 - Any
Updated:7/27/2016
Start Date:November 2013
End Date:January 2016

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Trial Summary
Trial Overview
Inclusion Criteria

Effect of Chemotherapy on Pain Sensitivity and Patient-reported Symptoms in Early Stage Breast Cancer

Many breast cancer survivors report chronic pain that develops or worsens following
chemotherapy. The impact of chemotherapy on the development of chronic pain is uncertain. In
this proposal, we are studying the impact of chemotherapy on a patient's sensitivity to
pain. We are also investigating whether a patient's sensitivity to pain is related to how
many symptoms she experiences during treatment.


Inclusion Criteria:

- Female gender

- Histologically proven stage I-III invasive carcinoma of the breast who is planning to
receive a standard dose of adjuvant chemotherapy.

- Surgical resection should be complete at the time of study enrollment.

- Eastern Cooperative Oncology Group performance status 0-2.

Exclusion Criteria:

- Average pain over the past 24 hours of 4 or greater on a 0-10 scale.

- Peripheral sensory neuropathy grade 2 or higher.

- Personal history of schizophrenia or major depressive disorder, or history of
suicidal ideation or attempt within the past 2 years.

- Thumbnail abnormalities on either hand (such as artificial nails) that are likely to
alter pain perception during testing.

- Pregnant or nursing.

- No prior chemotherapy for any reason
We found this trial at
1
site
University of Michigan Health System
1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
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Ann Arbor, MI
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