Cognitive Remediation of Schizophrenia in a Community Mental Health Setting
| Status: | Completed |
|---|---|
| Conditions: | Schizophrenia |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/6/2019 |
| Start Date: | September 2009 |
| End Date: | September 26, 2016 |
The purpose of this study is to investigate the usefulness of neuroscience-guided cognitive
training combined with community-based supported employment for people with schizophrenia.
The investigators will examine the effectiveness of moving our study of neuroplasticity-based
restorative targeted cognitive training out of the laboratory and into the community setting;
and the investigators will also investigate its utility in enhancing functional outcome in
chronically mentally ill adults who are participating in supported employment.
training combined with community-based supported employment for people with schizophrenia.
The investigators will examine the effectiveness of moving our study of neuroplasticity-based
restorative targeted cognitive training out of the laboratory and into the community setting;
and the investigators will also investigate its utility in enhancing functional outcome in
chronically mentally ill adults who are participating in supported employment.
Neurocognitive functioning will be assessed at baseline (study entry), after cognitive
training (6 months), and at 12 month follow-up, using the MATRICS Consensus Cognitive Battery
(MCCB). The investigators will assess the following six constructs identified by MATRICS as
separable, fundamental dimensions of cognitive impairment in schizophrenia, with a likely
sensitivity to intervention [26]: 1) Speed of Processing, 2) Attention/Vigilance, 3) Working
Memory, 4) Verbal Learning and Memory, 5) Visual Learning and Memory, and 6) Reasoning and
Problem Solving (executive functioning). The investigators will also administer the delayed
memory trials of HVLT and BVMT, Trails B, and D-KEFS Color-Word Interference Test [27], and
will make one modification to the MCCB in utilizing BACS Tower of London [28] in place of NAB
Mazes.
training (6 months), and at 12 month follow-up, using the MATRICS Consensus Cognitive Battery
(MCCB). The investigators will assess the following six constructs identified by MATRICS as
separable, fundamental dimensions of cognitive impairment in schizophrenia, with a likely
sensitivity to intervention [26]: 1) Speed of Processing, 2) Attention/Vigilance, 3) Working
Memory, 4) Verbal Learning and Memory, 5) Visual Learning and Memory, and 6) Reasoning and
Problem Solving (executive functioning). The investigators will also administer the delayed
memory trials of HVLT and BVMT, Trails B, and D-KEFS Color-Word Interference Test [27], and
will make one modification to the MCCB in utilizing BACS Tower of London [28] in place of NAB
Mazes.
Inclusion Criteria:
- diagnosis of schizophrenia or schizoaffective disorder(DSM-IV criteria)
- between the ages of 18-65
- English as primary language (learned before age 12)
- no major medical or neurological disorder that precludes participation in the study
Exclusion Criteria:
- We will not exclude subjects with substance abuse or dependence as we wish to
investigate the real-world effectiveness of this cognitive remediation approach when
combined with SE. As per the clinical policy at Community Services, however, patients
will not be permitted to attend the SE program or to participate in the study if they
are acutely intoxicated. Subjects who miss 5 consecutive days of participation due to
intoxication will be dropped and a replacement subject will be recruited.
We found this trial at
1
site
Click here to add this to my saved trials
