CYP2B6 Polymorphisms in Ketamine

Inclusion Criteria:

1. 18-50 yr old

2. CYP2B6*1/*1, CYP2B6*1/*6 or CYP2B6*6/*6 genotype (see table) (Note: subjects of other
rare genotype but with one or more 516G>T, 785A>G, 983T>C or 1459C>T polymorphism may
be enrolled at PI's discretion)

3. Good general health with no remarkable medical conditions

4. BMI <33

5. Provided informed consent

Exclusion Criteria:

1. Known history of liver or kidney disease

2. Use of prescription or non prescription medications, herbals, foods or chemicals known
to be metabolized by or affecting CYP2B6

3. Females who are pregnant or nursing

4. Known history of drug or alcohol addiction (prior or present addiction or treatment
for addiction)

5. Direct physical access to and routine handling of addicting drugs in the regular
course of duty (this is a routine exclusion from studies of drugs with addiction
potential)