Effect of Strawberries on Cardiovascular Disease Risk
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 20 - 50 |
| Updated: | 5/5/2014 |
| Start Date: | July 2013 |
| End Date: | August 2014 |
| Contact: | Ann Skulas-Ray, PhD |
| Email: | aus164@psu.edu |
| Phone: | 814-863-8622 |
Effects of a Freeze Dried Strawberry Powder on Postprandial Vascular Function and Blood Markers of Cardiovascular Risk
It is important to identify and evaluate foods, such as strawberries, that can improve
established and emerging cardiovascular risk factors, such as postprandial lipid and
glycemic responses, and vascular health. Postprandial derangements may affect multiple
metabolic pathways that lead to increased arterial stiffness. Research has demonstrated the
potential of strawberries to ameliorate postprandial responses to a high fat/high glucose
meal. Further research is needed to demonstrate this effect in better controlled clinical
studies and explore whether metabolic effects lead to improved arterial health.
The investigators propose to examine the effects of adding 40 g of freeze-dried strawberry
powder to a high fat/high glucose meal on postprandial cardiovascular risk factor including
lipids, insulin, glucose, and arterial stiffness and central blood pressure. The
investigators hypothesize that the bioactive components of strawberry powder will attenuate
postprandial lipemic and glycemic responses, as well as improve measures of arterial health.
established and emerging cardiovascular risk factors, such as postprandial lipid and
glycemic responses, and vascular health. Postprandial derangements may affect multiple
metabolic pathways that lead to increased arterial stiffness. Research has demonstrated the
potential of strawberries to ameliorate postprandial responses to a high fat/high glucose
meal. Further research is needed to demonstrate this effect in better controlled clinical
studies and explore whether metabolic effects lead to improved arterial health.
The investigators propose to examine the effects of adding 40 g of freeze-dried strawberry
powder to a high fat/high glucose meal on postprandial cardiovascular risk factor including
lipids, insulin, glucose, and arterial stiffness and central blood pressure. The
investigators hypothesize that the bioactive components of strawberry powder will attenuate
postprandial lipemic and glycemic responses, as well as improve measures of arterial health.
Inclusion Criteria:
- 20-50 years of age
- LDL-C below 160 mg/dL
- Triglycerides below 350 mg/dL
- No stage II hypertension (BP below 160/100 mmHg)
- Not taking medication for elevated lipids, blood pressure, or glucose
Exclusion Criteria:
- Allergies to strawberries
- Known intolerance to high fat meals
- History of cardiovascular disease, kidney disease, diabetes or inflammatory diseases
such as GI disorders and arthritis
- Use of non-steroidal anti-inflammatory or immunosuppressant drugs
- Conditions requiring the use of steroids
- Use of medication or supplements for elevated lipids, blood pressure or glucose
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