A Study of DNIB0600A in Comparison With Pegylated Liposomal Doxorubicin (PLD) in Participants With Platinum-Resistant Ovarian Cancer (PROC)

Inclusion Criteria:

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

- Histologically documented epithelial ovarian cancer, primary peritoneal cancer, or
fallopian tube cancer

- Advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer that has
progressed or relapsed during or within 6 months after the most recent treatment with
a platinum-containing chemotherapy regimen and for whom PLD is appropriate therapy

- No more than 1 prior cytotoxic chemotherapy regimens for the treatment of PROC and
not more than 2 total regimens (defined as any therapy [approved or investigational]
with intent to treat the ovarian cancer)

- Adequate hematologic, renal and liver function

- Willing and able to perform a patient-reported outcome (PRO) survey (including the
possibility of using an electronic PRO device)

- For women of childbearing potential, agreement to use 1 highly effective form of
contraception as defined by protocol through the course of study treatment and for 6
months after the last dose of study treatment

Exclusion Criteria:

- Primary platinum-refractory disease defined as disease progression during or within 2
months of a first-line, platinum-containing chemotherapy regimen

- Anti-tumor therapy, including chemotherapy, biologic, experimental, or hormonal
therapy, within 4 weeks prior to Day 1

- Palliative radiation within 2 weeks prior to Day 1

- Prior anthracycline therapy, including prior treatment with PLD (for example, Doxil®,
Caelyx®, or Lipodox®) in any setting (for example, in combination with carboplatin or
as a single agent)

- Prior treatment with NaPi2b or SCL34A2 targeted therapy

- Major surgical procedure within 4 weeks prior to Day 1

- Current Grade greater than (>) 1 toxicity (except alopecia and anorexia) from prior
therapy or Grade >1 neuropathy from any cause

- Left ventricular ejection fraction defined by multigated acquisition
(MUGA)/echocardiogram below the institutional lower limit of normal

- Evidence of significant, uncontrolled, concomitant disease that could affect
compliance with the protocol or interpretation of results, including significant
cardiovascular disease or significant pulmonary disease

- Known active infection, or any major episode of infection requiring treatment with IV
antibiotics or hospitalization (within 4 weeks prior to Cycle 1, Day 1)

- Clinically significant history of liver disease, including viral or other hepatitis,
current alcohol abuse, or cirrhosis

- Presence of positive test results for hepatitis B or hepatitis C as detailed in the
protocol

- Known history of HIV seropositive status

- Other malignancy within the last 5 years, except for adequately treated carcinoma in
situ of the cervix, squamous carcinoma of the skin, adequately controlled limited
basal cell skin cancer, or synchronous primary endometrial cancer or prior primary
endometrial cancer

- Untreated or active central nervous system metastases (progressing or requiring
anticonvulsants or corticosteroids for symptomatic control)

- Pregnancy or breastfeeding

- Known history of NaPi2b deficiency (for example, congenital alveolar microlithiasis
or testicular microlithiasis)

- History of severe allergic or anaphylactic reactions to monoclonal antibody therapy
(or recombinant antibody-related fusion proteins)

- Metabolic dysfunction, physical examination finding, or clinical laboratory find
giving reasonable suspicion of a disease or condition that contraindicated use of an
investigational drug or may render the participant at high risk from treatment
complications