Multiplex Testing for Breast Cancer Susceptibility: A Pilot Study of Subject Preferences for Information and Responses After Testing

Inclusion Criteria:

- Male or Female age 18 or older

- Personal history of breast cancer AND one of the following:

- Invasive breast cancer or DCIS diagnosed at or before age 45 Invasive breast cancer
diagnosed at/before age 50 with one or more of the following:

- Limited family history (Fewer than 2 first- or second-degree female relatives in the
same lineage that lived to age 45. The "limited family history" can occur on either
the maternal or paternal side of the family.)

- 1 or more first-/second-degree relatives with invasive BC at/before 50

- 1 or more first-/second-degree relatives with invasive epithelial ovarian cancer (any
age)

- 1 or more first- or second-degree relatives with male breast cancer

- 2 or more first- or second-degree relatives with pancreas cancer

- Invasive breast cancer diagnosed at or before age 60 with at least 2 first or
second-degree relatives affected with any combination of invasive breast cancer before
age 50, invasive epithelial ovarian cancer at any age, male breast cancer, or pancreas
cancer.

- Full sequence BRCA1 and BRCA2 testing completed with no deleterious mutation
identified.

Exclusion Criteria:

- Unable to provide informed consent for testing

- Unable to complete English language questionnaire