Multicenter Post-Approval Study Of The Glaukos® iStent® Trabecular Micro-Bypass Stent System In Conjunction With Cataract Surgery

The purpose of this study is to assess the long-term safety of the Glaukos® iStent®
Trabecular Micro-Bypass Stent Model GTS100 in conjunction with cataract surgery compared to
cataract surgery only, in subjects with mild to moderate open-angle glaucoma.

Inclusion Criteria:

- mild to moderate primary open-angle glaucoma

- currently treated with ocular hypotensive medication

- pseudoexfoliative and pigmentary glaucoma are acceptable diagnoses

- subject scheduled to undergo cataract surgery

Exclusion Criteria:

- primary angle-closure glaucoma; or secondary angle closure glaucoma, including
neovascular glaucoma

- retrobulbar tumor, thyroid eye disease, Sturge-Weber syndrome or any other type of
condition that may cause elevated episcleral venous pressure